Effect of Centipeda Herba Volatile Oil on Allergic Rhinitis by Nasal Sniffing  

作　　者：Xiang QIN Xiaoni PAN Yuan PAN Yanfeng MO Shuwen LI Tingting XIE Shiyou ZHOU Jiancheng LIANG Lixiang LU Suoyi HUANG 

机构地区：[1]School of Clinical Medicine,Youjiang Medical University for Nationalities,Baise 533000,China [2]School of Public Health and Management,Youjiang Medical University for Nationalities,Baise 533000,China [3]Key Laboratory of Research on Characteristic Ethnic Medicine in the Youjiang River Basin of Guangxi Colleges and Universities,Baise 533000,China

出　　处：《Medicinal Plant》2024年第6期79-82,共4页药用植物（英文）

基　　金：Supported by 2021 National Undergraduate Innovation and Entrepreneurship Project(202110599012).

摘　　要：[Objectives] To explore the efficacy of different concentrations of Centipeda Herba volatile oil in the treatment of allergic rhinitis (AR) by nasal sniffing and the optimal drug concentration.[Methods] Forty-eight mice were randomly divided into control group, blank group, alcohol treatment group, low concentration group, medium concentration group and high concentration group, with 8 mice in each group. Except for the blank group, each mouse in the other groups was intraperitoneally injected with 1 mL of a mixture of 50 μgOVA+5 mg [Al(OH)_(3)] +1 mL of normal saline for 14 d. The allergic rhinitis mouse model was successfully established by intranasal instillation of 5% OVA solution on both sides (20 μL per side, once a day) from the 15 th day after stimulation for 7 d. The blank group was treated with the same amount of saline as above. The volatile oil of Centipeda Herba was obtained by steam distillation and petroleum ether extraction, and then was made into 1.25%, 2.5% and 5% volatile oil of Centipeda Herba with 75% alcohol. The control group was stimulated once every other day with reagent 2 after 7 d of stimulation (maintenance) until the end of treatment. The blank group was treated with 5 mL saline by nasal sniffing for 30 d, twice in the morning and evening, 30 min each time. The alcohol treatment group was treated with 5 mL of 75% alcohol, and the low concentration group, the medium concentration group and the high concentration group were treated with 5 mL of 1.25%, 2.5% and 5% Centipeda Herba volatile oil, respectively. The treatment time was the same as that of the blank group, and the treatment process was carried out in their respective closed contamination boxes. Before and after the treatment, the frequency of sneezing, the frequency of scratching nose, the amount of nasal discharge, activity and other general characteristics of the mice were observed, and the allergic behavior score was carried out. Besides, the IgE content in the serum of the mice was determined, and the eosinophils in the

关 键 词：Allergic rhinitis Volatile oil of Centipeda Herba Nasal sniffing therapy IGE EOSINOPHIL 

分 类 号：R284[医药卫生—中药学]