Supported by 2021 National Undergraduate Innovation and Entrepreneurship Project(202110599012).
[Objectives] To explore the efficacy of different concentrations of Centipeda Herba volatile oil in the treatment of allergic rhinitis (AR) by nasal sniffing and the optimal drug concentration.[Methods] Forty-eight mi...
In this work, lateral deformation of human eosinophil cell during the lateral indentation by an optically trapped microbead of diameter 4.5 µm is studied. The images were captured using a CCD camera and the Boltzmann...
Department of Otolaryngological,Shanghai Changzheng Hospital,Grant/Award Number:0907;National ScienceFoundationof China,Grant/Award Numbers:81541038,81670905,81870702。
Background:Eosinophilic extracellular traps(EETs)are reticular complexes comprising deoxyribonucleic-Acid(DNA)fibers and granule proteins.Aims:EETs play a crucial role in antimicrobial host responses and are pathogeni...
Objective To observe the correlations of chest CT quantitative parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with blood eosinophil(EOS)level.Methods Chest CT data of 16...
supported by the Key Project of Social Development in Jiangsu Province(No.BE2020632);National Natural Science Foundation of China(Nos.82073446 and 82103735);CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-059);Nanjing Incubation Program for National Clinical Research Center(No.2019060001)
Objective:To assess the relationship between the severity of atopic dermatitis(AD)in children of varying weight categories and their serum 25-hydroxyvitamin D[25(OH)D]levels.Methods:The study population comprised 899 ...
supported by the National Natural Science Foundation of China(32370953 and 82072737);the Research Fund of Vanke School of Public Health,Tsinghua University.
With the development of new experimental techniques(e.g.,single-cell RNA sequencing(scRNA-seq),light sheet microscopy,and clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9),e...
Eosinophilia can be seen in almost all medical subspecialty patients.Delay in diagnostic workup and treatment is associated with significant morbidity and mortality.Clinical vigilance and timely referral for diagnosti...
Natural Science Foundation of Henan Province,Grant/Award Number:202300410259;Henan Postdoctoral Science Foundation,Grant/Award Number:202001043;China Postdoctoral Science Foundation,Grant/Award Number:2021T140184。
Background : SHARPIN (SHANK- associated RH domain interactor) is a component ofthe linear ubiquitination complex that regulates the NF- κB signaling pathway. To betterunderstand the function of SHARPIN, we sought to ...
Objective:Vitiligo is a chronic autoimmune depigmenting skin disorder.In this disease,the destruction of functional melanocytes can lead to reduced or absent pigmentation of the skin.Vitamin D deficiency has been repo...
the grants from the National Natural Science Foundation of China(No.32171255);Industrialization Cultivation Planning Project of Jilin Provincial Department of Education(No.JJKH20221168CY).
Charcot-Leyden crystals(CLCs)are the hallmark of many eosinophilic-based diseases,such as asthma.Here,we report that reduced glutathione(GSH)disrupts CLCs and inhibits crystallization of human galectin-10(Gal-10).GSH ...