Eosinophil extracellular traps in respiratory ailment:Pathogenic mechanisms and clinical translation  

作　　者：Shun-Yu Wu Bo-Yu Cai Tian-Yu Wang Zhi-Wen Cao Hu Peng Huan-Hai Liu 

机构地区：[1]Department of Otolaryngology,The Second Affiliated Hospital of the Naval Military Medical University(Shanghai Changzheng Hospital),Shanghai,China

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第3期213-224,共12页世界耳鼻咽喉头颈外科杂志（英文）

基　　金：Department of Otolaryngological,Shanghai Changzheng Hospital,Grant/Award Number:0907;National ScienceFoundationof China,Grant/Award Numbers:81541038,81670905,81870702。

摘　　要：Background:Eosinophilic extracellular traps(EETs)are reticular complexes comprising deoxyribonucleic-Acid(DNA)fibers and granule proteins.Aims:EETs play a crucial role in antimicrobial host responses and are pathogenic when overproduced or under degraded.EETs created by eosinophils appear to enable vital immune responses against extra-cellular pathogens,nevertheless,trap overproduction is evident in pathology.Materials&Methods:As considerably research is performed,new data affirmed that EETs can alter the outcome of respiratory ailment.Results:We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic,unresolved inflammation.Discussion:Whether EETs can be used as a prospective brand-new target for the diagnosis,treatment and prognosis of respiratory ailments is a scientific theme worth studying.Conclusion:We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic,unresolved inflammation.

关 键 词：CYTOLYSIS DEGRANULATION eosinophil extracellular traps eosinophils respiratory ailments 

分 类 号：R56[医药卫生—呼吸系统]