CYTOLYSIS

作品数：8被引量：18H指数：3
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相关领域：医药卫生更多>>
相关作者：王剑孙汭田志刚郑晓东魏海明更多>>
相关机构：中国科学技术大学更多>>
相关期刊：《Cellular & Molecular Immunology》《World Journal of Gastroenterology》《Open Journal of Gastroenterology》《Chinese Medical Sciences Journal》更多>>
相关基金：国家自然科学基金更多>>
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Eosinophil extracellular traps in respiratory ailment:Pathogenic mechanisms and clinical translation
《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第3期213-224,共12页Shun-Yu Wu Bo-Yu Cai Tian-Yu Wang Zhi-Wen Cao Hu Peng Huan-Hai Liu 
Department of Otolaryngological,Shanghai Changzheng Hospital,Grant/Award Number:0907;National ScienceFoundationof China,Grant/Award Numbers:81541038,81670905,81870702。
Background:Eosinophilic extracellular traps(EETs)are reticular complexes comprising deoxyribonucleic-Acid(DNA)fibers and granule proteins.Aims:EETs play a crucial role in antimicrobial host responses and are pathogeni...
关键词：CYTOLYSIS DEGRANULATION eosinophil extracellular traps eosinophils respiratory ailments 
Liver Damage during Dengue Fever in Ouagadougou
《Open Journal of Gastroenterology》2022年第9期221-231,共11页Alice Nanelin Guingané Judith Ouango Abdoulaye Sourabié Christiane Couna Bere Roger Sombié Alain Bougouma Abdel Karim Sermé Aboubacar Coulibaly Sosthène Somda 
Dengue fever is widespread in all tropical and subtropical areas of the world and is the main public health problem posed by arboviroses. In Burkina Faso, an outbreak of dengue serotype “DENV-2”, which is responsibl...
关键词：Dengue Fever Liver Damage CYTOLYSIS Hemorrhagic Fever 
Etiologies of Liver Cytolysis in the Service of Hepato-Gastroenterology of the Gabriel Toure University Hospital
《Open Journal of Gastroenterology》2021年第11期211-219,共9页Hourouma Sow wife Coulibaly Kadiatou Doumbia wife Samaké Moussa Younoussa Dicko Deborah Sanogo wife Sidibé Makan Siré Tounkara Ousmane Diarra Anselme Konaté Moussa Tiemoko Diarra Moussa Youssoufa Maiga 
Aggression to the liver by xenobiotic and endogenous agents essentially results in an increase in serum aminotransferases related to hepatic cytolysis, the diagnosis of which is not always easy due to the diversity of...
关键词：Liver Cytolysis TRANSAMINASES Etiology MALI 
Application of a novel inhibitor of human CD59 for the enhancement of complement-dependent cytolysis on cancer cells被引量：6
《Cellular & Molecular Immunology》2011年第2期157-163,共7页Tao You Weiguo Hu Xiaowen Ge Jingnan Shen Xuebin Qin 
the US NIH through grant RO1 AI061174(XBQ);grant R21 CA141324(XBQ);the Harvard Technology Development Accelerator Fund(XBQ),and the Fund of the China Scholarship Council No.2008638052(TY).
Many monoclonal antibodies(mAbs)have been extensively used in the clinic,such as rituximab to treat lymphoma.However,resistance and non-responsiveness to mAb treatment have been challenging for this line of therapy.Co...
关键词：CD59 COMPLEMENT lymphoma multiple myeloma RITUXIMAB 
Activity after Site-Directed Mutagenesis of CD59 on Complement-Mediated Cytolysis被引量：8
《Cellular & Molecular Immunology》2008年第2期141-146,共6页Xinhong Zhu Meihua Gao Shurong Ren Qiubo Wang Cunzhi Lin 
National Natural Science Foundation of China （No.30671936）.
CD59 may inhibit the cytolytic activity of complement by binding to C8/C9 and protect host cell membranes against homologous membrane attack complex （MAC）. However, CD59 is widely overexpressed on tumor cells, which...
关键词：CD59 COMPLEMENT active site site-directed mutagenesis overlap.extension PCR 
The Effect of Glycation of CD59 on Complement-Mediated Cytolysis被引量：3
《Cellular & Molecular Immunology》2005年第4期313-317,共5页Ying Cheng Meihua Gao 
supported by the National Natural Science Foundation of China(No.30170893)
Vascular proliferation is one of the major causes for morbidity and mortality in diabetes. However, the cellular and molecular mechanisms that link hyperglycemia to this complication remain unclear. In present study, ...
关键词：CD59 site-directed mutagenesis eukaryotic expression vector 
EXPRESSION OF HUMAN α-GALACTOSIDASE AND α1,2-FUCOSYL-TRANSFERASE GENES MODIFIES THE CELL SURFACE GALα1,3GAL ANTIGEN AND CONFERS RESISTANCETO HUMAN SERUM-MEDIATED CYTOLYSIS
《Chinese Medical Sciences Journal》2004年第1期31-37,共7页贾延军 任会明 高新 季守平 杨军 刘泽鹏 李素波 章扬培 
Thisstudywassupportedbythe248keyprogramofBeijingScienceandTechnologyCommittee.
Objective To explore the strategies which reduce the amount of xenoantigen Galα1, 3 Gal. Methods Human α-galactosidase gene and α1,2-fucosyltransferase gene were transferred into cul-tured porcine vascular endothel...
关键词：galactosidase gene hyperacute rejection Galα1 3Gal antigen 
Participation of CD45,NKR-P1A and ANK61 antigen in rat hepatic NK cell(pit cell)-mediated target cell cytotoxicity被引量：4
《World Journal of Gastroenterology》2000年第4期546-552,共7页David Vermiilen Bülent Ahishali Vasilis Triantis Karin Vanderkerken Peter J. K.Kuppen Eddie Wisse 
the grants 3.0053.92,3.0050.95,9.0038.96,1.5.411.98 from the National Foundation for Scientific Research(FWO);the grants 194.322.1740,195.332.1310,196.322.0140,and OZR.230 from the Research Council of the Free University of Brussels
AIM Several triggering receptors have beendescribed to be involved in natural killer（NK）cell-mediated target cytotoxicity.In these studies,NKcells derived from blood or spleen were used.Pitcells are liver-specific N...
关键词：HEPATIC NK CELLS pit CELLS CYTOLYSIS apoptosis perforin/granzyme pathway 
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