巨噬细胞活化相关因子与精神分裂症临床症状的关系  

Relationship between macrophage activation related factors and clinical symptoms of schizophrenia

作　　者：方姣 陈闻锦 郑文凯 勾梦壮 刘永利[2] 陈松[2] 李娜[2] 黄隽超 李艳丽[2] 潘淑娟[2] 谭云龙 ANG Jiao;CHEN Wenjin;ZHENG Wenkai;GOU Mengzhuang;LIU Yongli;CHEN Song;LI Na;HUANG Junchao;LI Yanli;PAN Shujuan;TAN Yunlong(Basic Medical College of Inner Mongolia Medical University,Hohhot O10110,China;Peking University Huilongguan Clinical Medical School,Beijing 100096,China)

机构地区：[1]内蒙古医科大学基础医学院,呼和浩特010110 [2]北京大学回龙观临床教学医院,北京100096

出　　处：《中国心理卫生杂志》2025年第1期1-7,共7页Chinese Mental Health Journal

基　　金：国家自然科学基金(82171507)。

摘　　要：目的:探讨巨噬细胞活化相关因子与精神分裂症(SCZ)临床症状的关系。方法:选取符合精神障碍诊断与统计手册第4版诊断标准的门诊或住院SCZ患者(n=166)和正常对照(n=71)为对象。采用阳性和阴性症状量表(PANSS)评估患者精神病理症状,用酶联免疫吸附法实验(ELISA)测定α-NaGalases、MAF和IL-18浓度。分析生物学指标和临床症状的相关性并进行中介效应检验。结果:SCZ组α-NaGalases (P<0.001)和MAF(P<0.01)浓度低于正常对照组。SCZ组中,IL-18与α-NaGalases浓度(r=-0.24,P<0.01)负相关;α-NaGalases与MAF浓度(r=0.67,P<0.001),PANSS阳性症状量表总分与IL-18 (r=0.21,P <0.05)、MAF浓度(r=0.22,P <0.01)正相关。α-NaGalases和MAF的中介效应有统计学意义,相对中介效应占比25.47%。结论:IL-18水平升高可能提示精神分裂症阳性症状的发生,α-NaGalases和MAF可能会负性调节IL-18对SCZ的炎性损伤作用,从而代偿性缓解阳性症状。Objective:To investigate the relationship between macrophage activation related factors and clinical symptoms of schizophrenia(SCZ).Methods:Outpatient or inpatient SCZ patients(n=166)and normal controls(n=71)meeting the diagnostic criteria of DSM 4th edition were selected as subjects.The psychopathological symptoms were assessed by the Positive and Negative Syndrome Scale(PANSS),and the concentrations of α-NaGalases,MAF and IL-18 were determined by enzyme-linked immunosorbent assay(ELISA).The correlation between biological indicators and clinical symptoms was analyzed and the mediation effect was tested.Results:The concentrations of α-NaGalases(P<0.001)and MAF(P<0.01)in SCZ group were lower than those in normal control group.In SCZ group,IL-18 was negatively correlated with α-NaGalases concentration(r=-0.24,P<0.01).α-NaGalases was positively correlated with MAF concentration(r=0.67,P<0.001),and the total score of PANSS positive symptom scale was positively correlated with IL-18(r=0.21,P<0.05)and MAF concentration(r=0.22,P<0.01).The mediating effect of α-NaGalases and MAF was statistically significant,and the relative mediating effect accounted for 25.47%.Conclusion:The increase of IL-18 level may indicate the occurrence of positive symptoms of schizophrenia,andα-NaGalases and MAF may negatively regulate the inflammatory damage effect of IL-18 on SCZ,thereby reducing the positive symptoms.

关 键 词：精神分裂症 白细胞介素-18 α-N-乙酰半乳糖胺酶 巨噬细胞活化因子 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R392.12[医药卫生—临床医学]