慢性痛与情感障碍共病研究新进展  

New progress on the study of comorbidity of chronic pain and affective disorders

作　　者：武胜昔 罗层 李珍珍 刘可欣 WU Shengxi;LUO Ceng;LI Zhenzhen;LIU Kexin(Department of Neurobiology,School of Basic Medical Sciences,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学基础医学院神经生物学教研室,陕西西安710032

出　　处：《空军军医大学学报》2024年第12期1341-1346,共6页Journal of Air Force Medical University

基　　金：国家自然科学基金创新研究群体项目(82221001);国家自然科学基金重点科学基金(82330036);国家自然科学基金青年科学基金(82201368);科技部科技创新2030-“脑科学与类脑研究”重大项目(2021ZD0203104);陕西省科技创新团队项目(2022TD-49)。

摘　　要：慢性痛是临床上常见的慢性疾病,发病率居高不下,且伴发疾病多样,不仅使患者出现睡眠障碍、无力等,甚至会产生焦虑、抑郁等情感障碍现象。同时,焦虑抑郁等情感障碍又会导致疼痛持续时间的延长和强度的加剧,二者相互调控,交互敏化,形成恶性循环,严重危害患者的生命质量。因此,如何缓解疼痛慢性化以及情感障碍共病的发生是神经科学与医学领域备受关注的热点及难点问题。近年来大量研究聚焦于慢性痛与情感障碍共病的临床研究、脑区调控以及分子机制等方向,并取得了突破性的进展。本文通过不同角度对慢性痛伴发情感障碍共病的发生、发展,以及潜在机制进行深入阐述,并对未来研究方向和临床转化作一展望,以期为慢性痛的深入研究与临床治疗提供指导。Chronic pain is a common chronic disease in clinical practice,with a high incidence rate and a variety of concomitant diseases,such as sleep disorders,fatigue,anxiety,and depression.Meanwhile,affective disorders such as anxiety and depression in turn lead to prolonged pain duration and exaggerated pain intensity,bringing about a vicious cycle between pain and affective disorders and endangering the quality of life of patients.Therefore,how to alleviate chronic pain and comorbid affective disorders is a hot and challenging issue in the field of neuroscience and medicine.In recent years,a large number of studies have focused on elucidating the underlying mechanisms and made breakthrough progress in the clinical investigation,brain region regulation and molecular basis in the development of comorbidity of chronic pain and affective disorders.This study summarizes the occurrence,development and potential mechanism of the comorbidity of chronic pain and affective disorders from different perspectives,and makes prospects for future research directions and clinical translation,aiming to provide guidance for the in-depth exploration and clinical treatment of chronic pain.

关 键 词：慢性痛 情感障碍 共病 细胞外基质 脑区调控 分子机制 

分 类 号：R749.4[医药卫生—神经病学与精神病学]