帕金森发病机制、药物治疗及早期生物标志物研究进展  

Research progress on pathogenesis,drug therapy and early biomarkers of Parkinson's disease

作　　者：吴恒 张鑫[2] 韩明明 张伟良 贾强 赛林霖 WU Heng;ZHANG Xin;HAN Mingming;ZHANG Weiliang;JIA Qiang;SAI Linlin(Shandong Academy of Occupational Health and Occupational Medicine,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250062,China;Jinan Southern Mountain Area Branch of Jinan Center for Disease Control and Prevention,Jinan 250113,China)

机构地区：[1]山东第一医科大学(山东省医学科学院),山东省职业卫生与职业病防治研究院,山东济南250062 [2]山东省济南市疾病预防控制中心济南市南部山区分中心,山东济南250113

出　　处：《空军军医大学学报》2024年第12期1483-1488,共6页Journal of Air Force Medical University

基　　金：山东省自然科学基金面上项目(ZR2023MH188);山东省医药卫生科技项目(202312010771);山东省中医药科技项目(M-2022255);济南市临床医学科技创新计划项目(202019108)。

摘　　要：帕金森病(PD)是最常见的神经退行性疾病之一,其典型的病理改变包括神经元和轴突中α-突触核蛋白阳性包涵体的形成和多巴胺能神经元的丢失。PD致病机制十分复杂,且目前没有任何药物被证明对PD有明确的治疗作用。大量研究证明PD的发生发展与免疫炎性、线粒体功能障碍密切相关。同时关于PD的药物开发,已在临床评估中研究了许多良好的治疗策略,基于其复杂的发病机制和各种病理因素的相互作用,迫切需要生物标志物的发现为早期诊断PD患者提供新方向。有效生物标志物的开发将会降低PD的发生风险,发掘更加有效的疾病治疗方法,实现PD的早期干预和治疗。Parkinson's disease(PD)is one of the most common neurodegenerative diseases,and its typical pathological changes include the formation ofα-synuclein positive inclusion bodies in neurons and axons and the loss of dopaminergic neurons.The pathogenesis of PD is very complex,and no drug has been proven to have a definite therapeutic effect on PD.A large number of studies have proved that immune inflammation and mitochondrial dysfunction are closely related to the occurrence and development of PD.At the same time,in the drug development of PD,many good treatment strategies have been studied in clinical evaluation,but its complex pathogenesis and interaction of various pathological factors urgently require the development of biomarkers to provide a new direction for the early diagnosis of PD patients.The development of effective biomarkers will reduce the risk of PD,explore more effective disease treatment methods,and realize early intervention and treatment of PD.

关 键 词：帕金森病 免疫炎症 线粒体功能障碍 生物标志物 

分 类 号：R742.5[医药卫生—神经病学与精神病学]