血清CA15-3、CEA和HER2与乳腺癌的相关性研究  

Research on the correlation study of Serum CA15-3,CEA,and HER2 with Breast Cancer progression

作　　者：童列杏 侯德法[1] 孟丽 刘伟 Tong Lianxing;Hou Defa;Meng Li;Liu Wei(Department of Laboratory,Fuyang Cancer Hospital,Fuyang 236800)

机构地区：[1]阜阳市肿瘤医院检验科,236800

出　　处：《现代科学仪器》2024年第6期30-33,共4页Modern Scientific Instruments

基　　金：安徽医科大学青年科学基金(项目编号:2022xkj114)。

摘　　要：目的:探讨CA15-3、CEA和HER2在乳腺癌(BCa)中的应用价值。方法:选择2018.10-2023.11来我院就诊的81例BCa患者为研究对象,分别行CEA、CA15-3、HER2检测,收集临床数据,分析CEA、CA15-3、HER2与年龄、绝经、肿瘤大小、转移的相关性以及比较各组CEA、CA15-3水平。结果:≤55与>55年龄组、肿瘤直径>2cm与≤2cm组、腋窝淋巴结转移组与非转移组、HER2阴性与阳性组CEA的水平,经t检验比较,P分别为0.575、0.011、0.048、0.031;以上各组CA15-3的水平经t检验比较,P<0.05。相关性分析示,CA-153、CEA与年龄、绝经、肿瘤大小、转移呈正相关,HER2与以上各组不相关。回归分析示,CEA、CA15-3和HER2为BCa严重程度的独立危险因素。结论:CA15-3、CEA和HER2为BCa严重程度的独立危险因素,实时监测CA15-3、CEA的水平和HER2阳性比值可评估BCa临床分期、复发和转移。Objective:To investigate the clinical application value of CA15-3,CEA,and HER2 in breast cancer(BCa).Methods:A total of 81 BCa patients who visited our hospital between October 2018 and November 2023 were selected as subjects.The levels of CEA,CA15-3,and HER2 were measured,and clinical data were collected.The correlation of CEA,CA15-3,and HER2 with age,menopause,tumor size,and metastasis was analyzed,and the levels of CEA and CA15-3 were compared between different groups.Results:The t-test comparison of CEA levels between the groups of≤55 and>55 years,tumor diameter>2 cm and≤2 cm,axillary lymph node metastasis and non-metastasis,and HER2-negative and HER2-positive groups showed P values of 0.575,0.011,0.048,and 0.031,respectively.The levels of CA15-3 in these groups were also compared by t-test,with P<0.05 in all cases.Correlation analysis indicated that CA15-3 and CEA were positively correlated with age,menopause,tumor size,and metastasis,while HER2 was not correlated with any of these factors.Regression analysis indicated that CEA,CA15-3,and HER2 were independent risk factors for the severity of BCa.Conclusion:CA15-3,CEA,and HER2 are independent risk factors for the severity of BCa.Real-time monitoring of CA15-3,CEA levels,and HER2 positivity can help assess the clinical stage,recurrence,and metastasis of BCa.

关 键 词：新型电化学发光免疫全自动分析仪 乳腺癌 转移 肿瘤标志物 

分 类 号：R737.9[医药卫生—肿瘤]