肺癌患者术后使用艾司氯胺酮自控静脉镇痛的效果研究  

Study on the Effect of Postoperative Self-controlled Intravenous Analgesia with Ketamine in Lung Cancer Patients

作　　者：张斌[1] 叶帅[1] 季红霞 宋炳炎 陈永红[1] Zhang Bin;Ye Shuai;Ji Hongxia;Song Bingyan;Chen Yonghong(Affiliated Nantong Hospital of Shanghai University,The Sixth People’s Hospital of Nantong,Nantong,Jiangsu 226000)

机构地区：[1]上海大学附属南通医院·南通市第六人民医院,江苏南通226000

出　　处：《科技与健康》2024年第22期5-8,共4页Technology and Health

基　　金：南通市卫生健康委员会科研课题“艾司氯胺酮超前镇痛联合自控镇痛对胸腔镜肺癌根治患者术后情绪及镇痛效果的影响”(MSZ2023063)。

摘　　要：探讨艾司氯胺酮在肺癌患者术后自控静脉镇痛中的应用效果。选取2021年6月—2024年6月南通市第六人民医院收治的102例肺癌手术患者进行对比试验。采取盲抽法将患者分为两组,分别为对照组和观察组,每组各51例,对照组采用舒芬太尼+阿扎司琼进行镇痛,观察组在此基础上联合应用艾司氯胺酮,比较两组患者的镇痛效果。结果显示,观察组术后不同时间段舒芬太尼用量明显少于对照组(P<0.05);观察组术后不同时间段的疼痛评分均低于对照组(P<0.05)。观察组患者的不良反应总发生率低于对照组(P<0.05)。研究发现,在肺癌患者术后自控静脉镇痛中应用艾司氯胺酮可有效减少舒芬太尼用量,减轻患者的疼痛感,切实改善患者的负性情绪及睡眠质量,降低不良反应发生风险。Exploring the application effect of ketamine in postoperative patient-controlled intravenous analgesia for lung cancer patients.102 lung cancer surgical patients admitted to the Sixth People’s Hospital of Nantong from June 2021 to June 2024 were selected for a comparative experiment.The patients were randomly divided into two groups,a control group and an observation group,with 51 patients in each group.The control group was treated with sufentanil and azasetron for analgesia,while the observation group was treated with a combination of ketamine and esketamine for analgesia.The analgesic effects of the two groups of patients were compared.The results showed that the dosage of sufentanil in the observation group was significantly lower than that in the control group at different time points after surgery(P<0.05);The pain scores of the observation group at different time points after surgery were lower than those of the control group(P<0.05).The overall incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Research has found that the use of ketamine in postoperative patient-controlled intravenous analgesia for lung cancer patients can effectively reduce the dosage of sufentanil,alleviate patient pain,effectively improve negative emotions and sleep quality,and reduce the risk of adverse reactions.

关 键 词：肺癌 艾司氯胺酮 自控静脉镇痛 效果 

分 类 号：R734.2[医药卫生—肿瘤]