GPER在TNBC中介导的相关通路分析  

Analysis of Mediated Related Pathways of GPER in TNBC

作　　者：沈俊杰 邓欣宇 Shen Junjie;Deng Xinyu(Southwest Medical University,Luzhou 646000,China)

机构地区：[1]西南医科大学,四川泸州646000

出　　处：《黑龙江科学》2024年第24期131-134,共4页Heilongjiang Science

基　　金：2024年省级大学生创新创业项目“基于GPER介导途径探究大豆苷元对三阴乳腺癌生长和转移的作用及机制”(S202310632213)阶段性成果。

摘　　要：三阴性乳腺癌(TNBC)是乳腺肿瘤中最具侵袭性的分子亚型,占所有乳腺癌的10%~15%,且预后最差。其特点是缺乏雌激素受体(ER)和孕激素受体(PR)表达,缺乏人表皮生长因子受体2(ERBB2/HER2)过表达或基因扩增,故早期TNBC被认为是一种不依赖雌激素的乳腺癌。乳腺癌的治疗主要包括激素治疗、抗HER2治疗和化疗,故TNBC长期以来缺乏有效的靶向治疗和精确的治疗选择,直到G蛋白偶联雌激素受体(GPER)的发现才揭示出TNBC的雌激素介导通路。有研究表明GPER与TNBC促转移途径有关,这些结果为研究GPER介导雌激素在TNBC中的致癌作用提供了新的见解,为TNBC的治疗提供了新思路。综述了与GPER相关的各通路及其作为TNBC潜在治疗靶点的合理性,为探究治疗TNBC的有效作用通路提供理论基础。Triple-negative breast cancer(TNBC)is the most aggressive molecular subtype of breast cancer,accounting for 10%~15%of all breast cancers.It has the worst prognosis.It is characterized by lack of estrogen receptor(ER)and progesterone receptor(PR)expression,human epidermal growth factor receptor 2(ERBB2/HER2)overexpression or gene amplification,so early TNBC is considered to be an estrogen-independent breast cancer.The treatment of breast cancer mainly includes hormone therapy,anti-HER2 therapy and chemotherapy.So TNBC has lacked effective targeted therapy and precise treatment options for a long time.Until the discovery of G protein-coupled estrogen receptor(GPER),the estrogen-mediated pathway of TNBC is revealed.Some studies have shown that GPER is related with TNBC promoting metastasis pathway.These results provide new insights into the carcinogenic effect of GPER mediating estrogen in TNBC,and provide new ideas for the treatment of TNBC.The study reviews the pathways related with GPER and their rationality as potential therapeutic targets for TNBC,so as to provide a theoretical basis for exploring the effective pathways for TNBC treatment.

关 键 词：三阴性乳腺癌 G蛋白偶联雌激素受体 雌激素 信号通路 

分 类 号：R737.9[医药卫生—肿瘤]