血管内皮生长因子抑制剂在胆管细胞癌治疗中的应用进展  

Effects of VEGF inhibitors for treating cholangiocarcinoma:A review of literature

作　　者：张建芳 孙雪琴 崔叶谦 陈洋 王绍波[1] ZHANG Jianfang;SUN Xueqin;CUI Yeqian;CHEN Yang;WANG Shaobo(Nuclear Medicine Department,the First People′s Hospi-tal of Yunnan Province,the Affiliated Hospital of Kunming University of Science and Technology,Kunming 650500,Yunnan,China;Medical school,Kunmin University of Science and Technology,Kunming 650500,Yunnan,China;不详)

机构地区：[1]昆明理工大学附属医院/云南省第一人民医院核医学科,云南昆明650500 [2]昆明理工大学医学部,云南昆明650500

出　　处：《实用医学杂志》2024年第24期3554-3560,共7页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:B146-82260355);云南省科技厅科技计划项目(编号:202403AC100018,202301AY070001-211)。

摘　　要：胆管细胞癌(cholangiocarcinoma,CCA)是一种起源于胆管上皮细胞的恶性肿瘤,侵袭性高、预后较差。手术为首选治疗,但因多数患者确诊晚,手术效果不佳,通常需依赖化疗等综合治疗,然而中位生存期依然很短,迫切需要新策略。血管内皮生长因子(vascular endothelial growth factor,VEGF)作为血管生成的重要因素,常在CCA患者肿瘤细胞中高表达。近年研究表明,VEGF促进血管生成,加剧CCA的侵袭和转移。VEGF抑制剂作为治疗CCA的新兴手段,为实现精准医疗打开了新的窗口。采用VEGF抑制剂靶向治疗联合免疫治疗、化疗等方法可有效延长患者的生存期,为改善患者的生活质量带来了新的希望。本文综述了VEGF在CCA中的表达情况和肿瘤发展中的作用机制,以及VEGF抑制剂在CCA治疗中的应用进展。Cholangiocarcinoma(CCA)is an aggressive malignant tumor originating from bile duct epithelial cells,characterized by a poor prognosis.Surgery is the primary treatment,but late diagnosis often leads to poor surgical outcomes.Consequently,patients typically rely on comprehensive treatment such as chemotherapy.However,the median survival remains short,highlighting the urgent need for new strategies.Vascular endothelial growth factor(VEGF),a crucial factor in angiogenesis,is frequently overexpressed in tumor cells of CCA patients.Recent studies have shown that VEGF not only promotes angiogenesis but also exacerbates the invasion and metastasis of CCA.Therefore,targeting VEGF-mediated angiogenesis provides a new strategy for treating CCA.VEGF inhibitors represent a new frontier in CCA treatment,offering opportunities for precision therapy.By integrating VEGF inhibitors with immunotherapy and chemotherapy,it is possible to not only effectively prolong the survival of CCA patients but also to offer new hope for improving their quality of life.This review examines the expression of VEGF in CCA,its role in tumorigenesis,and the clinical application of VEGF inhibitors in treating CCA.

关 键 词：胆管细胞癌 抑制剂 血管内皮生长因子 

分 类 号：R735.8[医药卫生—肿瘤]