TNFSF15基因多态性与溃疡性结肠炎相关性的meta分析  

Association between TNFSF15 gene polymorphism and ulcerative colitis:a meta-analysis

作　　者：曹国栋 王伟强[1] 唐光明[1] CAO Guodong;WANG Weiqiang;TANG Guangming(Department of Gastroenterology,Chongqing Seventh People′s Hospital,Chongqing 400054,China)

机构地区：[1]重庆市第七人民医院消化内科,重庆400054

出　　处：《现代医药卫生》2024年第24期4266-4271,共6页Journal of Modern Medicine & Health

摘　　要：目的系统评价人类肿瘤坏死因子超家族成员15(TNFSF15)基因在rs3810936位点的C/T多态性与溃疡性结肠炎(UC)的相关性。方法通过计算机检索EMbase、PubMed、Ovid、Springer、中国知网、万方医学网、维普资讯中文期刊服务平台等数据库,搜索关于TNFSF15基因在rs3810936位点C/T多态性与UC相关性的病例对照研究,检索时限为建库至2024年2月。由2位研究者独立进行文献筛选、资料提取及纳入研究偏倚风险评价后使用Review Manager 5.3、Stata 12.0软件进行meta分析。结果最终纳入9项病例对照研究,共2173例UC患者(病例组)和2744例健康者(对照组)。TNFSF15基因在rs3810936位点C/T多态性与UC发病风险具有相关性,携带CC+CT、CC基因型者UC发病风险均高于TT基因型,携带CT+TT基因型者UC发病风险低于CC基因型,携带C等位基因者UC发病风险高于T等位基因,差异均有统计学意义(优势比=1.25、1.41、0.82、1.17,95%可信区间1.06~1.46、1.17~1.71、0.71~0.93、1.08~1.27,P=0.006、<0.001、0.003、<0.001)。结论TNFSF15基因在rs3810936位点C/T多态性与UC发病有关,携带等位基因C会增加UC的发病风险。但受纳入研究数量和质量限制,该结论仍需开展大样本、高质量的研究进行验证。Objective To systematically evaluate the association between the C/T polymorphism at the rs3810936 locus of the tumor necrosis factor superfamily member 15(TNFSF15)gene and ulcerative colitis(UC).Methods Databases including EMbase,PubMed,Ovid,Springer,CNKI,Wanfang Data,VIP Information(Chinese Journal Service Platform),and others were searched for case-control studies on the association between the C/T polymorphism at the rs3810936 locus of the TNFSF15 gene and UC,from inception to February 2024.Two researchers independently screened the literature,extracted data,and assessed the risk of bias in the included studies.Meta-analysis was conducted using Review Manager 5.3 and Stata 12.0 software.Results A total of 9 case-control studies were included,involving 2173 UC patients(case group)and 2744 healthy individuals(control group).The C/T polymorphism at the rs3810936 locus of the TNFSF15 gene was associated with the risk of UC.Individuals carrying the CC+CT and CC genotypes had a higher risk of UC than those with the TT genotype.Those carrying the CT+TT genotype had a lower risk of UC than those with the CC genotype.Individuals carrying the C allele had a higher risk of UC than those with the T allele,with statistically significant differences(odds ratios=1.25,1.41,0.82,1.17;95%confidence intervals 1.06-1.46,1.17-1.71,0.71-0.93,1.08-1.27;P=0.006,<0.001,0.003,<0.001).Conclusion The C/T polymorphism at the rs3810936 locus of the TNFSF15 gene is associated with the development of UC,and carrying the C allele increases the risk of UC.However,due to the limitations of the number and quality of the included studies,this conclusion still needs to be verified by large-sample,high-quality studies.

关 键 词：肿瘤坏死因子超家族成员15 溃疡性结肠炎 基因多态性 META分析 

分 类 号：R574.62[医药卫生—消化系统]