扶正消瘤汤对乳腺癌术后患者免疫功能和远期疗效的影响  

The effect of Fuzheng Xiaoliu decoction on immune function and long-term curative effect of postoperative patients with breast cancer

作　　者：杨微微 吕继维 YANG Wei-wei;LYU Ji-wei(Department of Oncology,Chaoyang Hospital of Traditional Chinese Medicine,Chaoyang 122000,China)

机构地区：[1]朝阳市中医院肿瘤科,122000 [2]吉林经济技术开发区医院,132115

出　　处：《中国现代药物应用》2024年第23期134-137,共4页Chinese Journal of Modern Drug Application

摘　　要：目的观察扶正消瘤汤对乳腺癌术后患者免疫功能和远期疗效的影响。方法50例乳腺癌术后患者,按随机数字表法分成观察组及对照组,各25例。对照组术后3周内开始行辅助化疗,观察组在对照组基础上加用扶正消瘤汤治疗。比较两组患者治疗效果、转移率和局部复发率,治疗后的中医证候积分、血清肿瘤标志物及免疫功能指标。结果观察组的治疗总有效率为92.00%,转移率为12.00%,局部复发率为12.00%;对照组的治疗总有效率为68.00%,转移率为36.00%,局部复发率为36.00%。观察组的治疗总有效率显著高于对照组,转移率、局部复发率显著低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的神疲乏力、失眠、口干、出汗、乳房胀痛积分显著低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原153(CA153)水平分别为(2.98±1.30)μg/L、(18.02±6.13)U/ml、(13.72±3.58)U/ml,显著低于对照组的(4.64±2.17)μg/L、(29.75±8.61)U/ml、(21.85±7.46)U/ml,差异有统计学意义(P<0.05)。治疗后,观察组的CD3^(+)(1250±200)cells/μl、CD4^(+)(850±150)cells/μl、CD4^(+)/CD8^(+)(2.1±0.4)均显著高于对照组(1050±180)cells/μl、(700±120)cells/μl、(1.7±0.3),而CD8^(+)(400±80)cells/μl低于对照组的(450±90)cells/μl,差异有统计学意义(P<0.05)。结论相较于单独化疗,通过化疗联合扶正消瘤汤治疗乳腺癌术后患者能够减轻不适症状,增加免疫水平,并减少血清中肿瘤标志物的浓度,减少转移和复发情况,其效果显著,可以推广使用。Objective To observe the effect of Fuzheng Xiaoliu decoction on immune function and long-term curative effect of postoperative patients with breast cancer.Methods 50 postoperative patients with breast cancer were divided into an observation group and a control group according to random numerical table,with 25 cases in each group.The control group received adjuvant chemotherapy within 3 weeks after operation,and the observation group was treated with Fuzheng Xiaoliu decoction on the basis of the control group.The therapeutic effect,metastasis rate,local recurrence rate,traditional Chinese medicine syndrome score,serum tumor markers and immune function indexes after treatment were compared between the two groups.Results In the observation group,the total effective rate was 92.00%,the metastasis rate was 12.00%and the local recurrence rate was 12.00%;in the control group,the total effective rate was 68.00%,the metastasis rate was 36.00%and the local recurrence rate was 36.00%.The total effective rate of treatment in the observation group was significantly higher than that in the control group,and the metastasis rate and local recurrence rate were significantly lower than those in the control group.The difference was statistically significant(P<0.05).After treatment,the scores of fatigue,insomnia,dry mouth,sweating and breast tenderness in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CEA,CA125 and CA153 in the observation group were(2.98±1.30)μg/L,(18.02±6.13)U/ml and(13.72±3.58)U/ml,which were significantly lower than(4.64±2.17)μg/L,(29.75±8.61)U/ml and(21.85±7.46)U/ml in the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had CD3^(+) of(1250±200)cells/μl,CD4^(+) of(850±150)cells/μl,and CD4^(+)/CD8^(+)of(2.1±0.4),which were significantly higher than(1050±180)cells/μl,(700±120)cells/μl,and(1.7±0.3)in the control group;th

关 键 词：乳腺癌 扶正消瘤汤 化疗 免疫功能 肿瘤标志物 远期疗效 

分 类 号：R737.9[医药卫生—肿瘤]