腹泻灸联合厚朴三物汤加味方对乳腺癌化疗相关性恶心呕吐患者的效果观察  

Effect of diarrhea moxibustion combined with modified Houpo Sanwu decoction on chemotherapy-induced nausea and vomiting in patients with breast cancer

作　　者：张静[1] 杨双利 韦柳红[1] 张艳芳[1] 唐金珠 LIU Rong XIA Yong ZHANG Jing;YANG Shuangli;WEI Liuhong;ZHANG Yanfang;TANG Jinzhu;LIU Rong;XIA Yong(Liuzhou Workers'Hospital,Liuzhou,545005,Guangxi,China)

机构地区：[1]柳州市工人医院,广西柳州545005

出　　处：《肿瘤药学》2024年第5期584-588,共5页Anti-Tumor Pharmacy

基　　金：广西壮族自治区中医药管理局科研基金项目(GZZC2020309);广西壮族自治区卫生健康委科研基金项目(Z20210205)。

摘　　要：目的探讨腹泻灸联合厚朴三物汤加味方对乳腺癌化疗相关性恶心呕吐的效果。方法收集2022年1月到2023年1月我院肿瘤科乳腺癌术后辅助化疗住院患者124例,根据随机数字表法将患者分为对照组(n=62)与观察组(n=62)。对照组患者给予盐酸托烷司琼静脉滴注,每次5 mg,每天1次,共3天;观察组患者在对照组基础上配合使用腹泻灸和厚朴三物汤加味方,每天1次,共7天。比较两组患者恶心、呕吐、食欲减退的控制效果,生活质量(QOL)评分,卡氏功能状态(KPS)评分及血清5-羟色胺(5-HT)水平,并进行安全性分析。结果与对照组比较,观察组患者急性及延迟性恶心、呕吐的控制有效率均显著升高(P<0.05)。观察组患者延迟性及急性食欲减退的控制有效率与对照组比较,差异无统计学意义(P>0.05)。与干预前比较,两组患者干预后KPS、QOL评分均显著升高(P<0.05),且观察组显著高于对照组(P<0.05)。化疗后第7 d,两组患者血清5-HT水平均显著升高(P<0.05),但观察组升高幅度小于对照组(P<0.05)。结论腹泻灸联合厚朴三物汤加味方对乳腺癌化疗相关性恶心、呕吐疗效较好,有助于缓解恶心、呕吐症状,提高患者生活质量,降低血清5-HT水平,值得临床推广应用。Objective To explore the effect of diarrhea moxibustion combined with modified Houpo Sanwu decoction on chemotherapy-related nausea and vomiting in breast cancer patients.Methods 124 inpatients with postoperative adjuvant chemotherapy for breast cancer in the oncology department of our hospital were collected from January 2022 to January 2023.They were divided into the control group(n=62)and the observation group(n=62)according to the random number ta-ble.The control group was given tropisetron hydrochloride intravenously,5 mg each time,once a day,for a total of 3 days;On the basis of the control group,the observation group was given diarrhea moxibustion and modified Houpo Sanwu decoc-tion once a day for 7 days.The control effects of nausea,vomiting and anorexia were compared between the two groups,and the quality of life(QOL)and Karnofsky performance status(KPS)scores,serum 5-hydroxytryptamine(5-HT)levels were compared between the two groups.Results Compared with the control group,the observation group showed a significant in-crease in the effective rate of acute and delayed nausea/vomiting control(P<0.05).The effective rate of controlling delayed and acute appetite loss in the observation group was higher than that in the control group,but there was no significant differ-ence(P>0.05).Compared with before intervention,both groups showed an increase in KPS and QOL scores after interven-tion(P<0.05),and the KPS and QOL scores in the observation group were higher than those in the control group(P<0.05).On the 7th day after chemotherapy,the serum 5-HT levels in both groups significantly increased(P<0.05),but the increase in the observation group was smaller than that in the control group(P<0.05).Conclusion Diarrhea moxibustion combined with modified Houpo Sanwu decoction has a good effect on chemotherapy-induced nausea and vomiting in breast cancer pa-tients.It is helpful to alleviate nausea and vomiting symptoms,improve the quality of life of patients,and reduce the serum 5-HT level.It is worthy of clinical applica

关 键 词：乳腺癌 化疗相关性恶心呕吐 腹泻灸 厚朴三物汤加味方 5-羟色胺 

分 类 号：R737.9[医药卫生—肿瘤]