NLR、PLR对术前舌鳞状细胞癌颈淋巴结转移的诊断价值分析  

Analysis of the diagnostic value of NLR and PLR in cervical lymph node metastasis of tongue squamous cell carcinoma before surgery

作　　者：程龙龙 张诗涵 孟鑫 张静睿 周莹 王永功 CHENG Longlong;ZHANG Shihan;MENG Xin;ZHANG Jingrui;ZHOU Ying;WANG Yonggong(Henan University School of Stomatology,Kaifeng 475001;Department of Oral and Maxillofacial Surgery,Henan Provincial People's Hospital,Zhengzhou 450003;Department of Stomatology,Nanyang Second People's Hospital,Nanyang 473000,China)

机构地区：[1]河南大学口腔医学院,开封475001 [2]河南省人民医院口腔颌面外科,郑州450003 [3]南阳市第二人民医院口腔科,南阳473000

出　　处：《口腔颌面外科杂志》2024年第6期453-458,共6页Journal of Oral and Maxillofacial Surgery

基　　金：国家重点研发计划(2018YFC0114505)。

摘　　要：目的:分析术前血液炎症指标诊断舌鳞状细胞癌(tongue squamous cell carcinoma,TSCC)患者颈淋巴结转移的临床价值。方法:纳入2017年1月至2023年6月于河南省人民医院行手术治疗的141例TSCC患者,根据术后病理结果分为颈淋巴结转移组和颈淋巴结未转移组,收集患者手术前外周血炎症细胞(中性粒细胞、血小板和淋巴细胞)指标,并计算中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)和血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR),分析术前NLR及PLR诊断TSCC患者颈淋巴结转移的价值。结果:颈淋巴结转移组的NLR及PLR值明显高于颈淋巴结未转移组。NLR及PLR诊断TSCC患者颈淋巴结转移的曲线下面积和最佳截断值分别为0.72、2.24和0.61、115.43。多因素Logistic回归分析结果显示,NLR是TSCC患者颈淋巴结转移的独立影响因素。结论:术前炎症指标NLR可能是评估TSCC患者颈淋巴结转移的潜在标志物。Objective:To analyze the clinical value of preoperative blood inflammatory markers in diagnosing cervical lymph node metastasis in patients with tongue squamous cell carcinoma(TSCC).Methods:A total of 141 TSCC patients who underwent surgical treatment in Henan Provincial People's Hospital from January 2017 to June 2023 were included.According to the postoperative pathological results,they were divided into cervical lymph node metastatic group and cervical lymph node non-metastatic group.The index of peripheral blood inflammatory cells(neutrophil,platelet,and lymphocyte count values)were collected from patients before surgery,and the neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)were calculated to analyze the value of preoperative NLR and PLR in diagnosing cervical lymph node metastasis in TSCC patients.Results:The NLR and PLR values in cervical lymph node metastatic group were significantly higher than those in the cervical lymph node non-metastatic group.The area under the curve(AUC)and optimal cutoff values for diagnosing cervical lymph node metastasis in TSCC patients using NLR and PLR are 0.72,2.24 and 0.61,115.43,respectively.Multivariate logistic regression analysis showed that NLR is an independent influencing factor for cervical lymph node metastasis in TSCC patients.Conclusion:The preoperative inflammatory marker NLR may be a potential biomarker for evaluating cervical lymph node metastasis in TSCC patients.

关 键 词：舌鳞状细胞癌 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 颈淋巴结转移 

分 类 号：R782[医药卫生—口腔医学] R739.8[医药卫生—临床医学]