角蛋白在口腔鳞状细胞癌中的研究进展  

Research progress of keratin in oral squamous cell carcinoma

作　　者：王晓虎 王佐林[1] WANG Xiaohu;WANG Zuolin(Shanghai Engineering Research Center of Tooth Restoration and Regeneration&Tongji Research Institute of Stomatology&Department of Oral Implantology,Shanghai Tongji Stomatological Hospital and Dental School,Tongji University,Shanghai 200072,China)

机构地区：[1]上海市同济口腔医院口腔种植科,同济大学口腔医学院,上海牙组织修复与再生工程技术研究中心,同济大学口腔医学研究所,上海200072

出　　处：《口腔颌面外科杂志》2024年第6期470-472,共3页Journal of Oral and Maxillofacial Surgery

基　　金：科技部重点研发专项(2018YFE0202200);国家自然科学基金(81670962);同济大学中央高校基本业务费专项资金(22120180196)。

摘　　要：角蛋白(keratin,KRT)是细胞骨架蛋白中间丝家族的成员之一,主要分布在上皮细胞胞质中,对维持上皮细胞的形态和细胞间连接起主要作用。除此之外,角蛋白还通过调节上皮细胞增殖、迁移、分化及上皮间充质转化(epithelial-mesenchymal transformation,EMT),参与鳞状细胞癌的发生和发展。口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是口腔常见的恶性肿瘤,患者预后较差,生存率较低。近年来,角蛋白在OSCC中的研究逐渐增多,本文就角蛋白的生物学功能及其在OSCC中的研究进展进行阐述。Keratin(KRT)is one of the members of the cytoskeletal protein intermediate filament family mainly distributed in the cytoplasm of epithelial cells,which plays a significant role in maintaining the morphology of epithelial cells and intercellular connections.In addition,KRT also participates in the occurrence and development of squamous cell carcinoma by regulating epithelial cell proliferation,migration,differentiation and epithelial-mesenchymal transformation(EMT).Oral squamous cell carcinoma(OSCC)is a common malignant tumor of the oral cavity which usually has a poor prognosis and low survival rate in patients.In recent years,the research on KRT in OSCC has gradually increased,and this paper expounds on the biological function of keratin and its research progress in OSCC.

关 键 词：角蛋白 口腔鳞状细胞癌 上皮间充质转化 

分 类 号：R782[医药卫生—口腔医学]