药用辅料在中药制剂中的应用研究进展  

Advances in research on the application of pharmaceutical excipients in traditional Chinese medicine preparations

作　　者：缪妍 胡丽琴 张珂 钱帅[1] 高缘[1] 张建军[2] 魏元锋[1] MIAO Yan;HU Liqin;ZHANG Ke;QIAN Shuai;GAO Yuan;ZHANG Jianjun;WEI Yuanfeng(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198;School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学中药学院,南京211198 [2]中国药科大学药学院,南京211198

出　　处：《中国药科大学学报》2024年第6期734-741,共8页Journal of China Pharmaceutical University

基　　金：国家自然科学基金项目(No.82274217,No.82373824,No.82474088)。

摘　　要：药用辅料作为制剂不可或缺的关键部分,扮演着充当药物载体、改善药物释放、保障药品稳定性及提高患者顺应性的重要角色。中医药在我国有着悠久的历史,随着科学技术的现代化发展,药学、化学与材料学深度交叉融合,为中药制剂的创新研发提供了更为广阔的空间,而与此同时制药行业对优质辅料的需求也日益凸显。本文旨在综述中药制剂辅料的研究进展,具体涵盖预混与共处理辅料、物理及化学改性辅料、“药辅合一”辅料包括矫味剂、填充剂、促透剂及在递送系统中的应用等,通过对现有研究的梳理与分析,探讨各类辅料在中药制剂中的具体应用现状,以期为中药制剂辅料的选择提供思路,并促进中药制剂辅料领域的创新活力,呼吁开发适合中药制剂的个性化辅料。Pharmaceutical excipients,as an indispensable part of drug preparation,play crucial roles as drug carriers,improving drug release,ensuring drug stability,and enhancing patient compliance.Traditional Chinese Medicine(TCM)boasts a rich developmental history.With the modernization of technology,the deep integration of pharmacy,chemistry,and materials science has provided broader opportunities for innovative research in TCM.Simultaneously,the demand for high-quality excipients has become increasingly critical.This paper aims to review current research and applications of excipients in TCM preparations,including pre-mixed and coprocessed excipients,modified excipients,and the unification of drugs and excipients,such as flavoring agents,fillers,penetration enhancers,and delivery systems.A meticulous synthesis and analysis of existing research aims to provide a reference for selecting excipients in TCM preparations,stimulate innovation in excipient development for TCM,and advocate for the development of personalized excipients.

关 键 词：药用辅料 中药制剂 预混与共处理辅料 改性辅料 药辅合一 

分 类 号：R944[医药卫生—药剂学]