Research progress of Chinese herbal medicines and classic prescriptions in the treatment ofCOPD based on the TCM theory and medicinal characteristics  

作　　者：Qian Luo Bo Peng Xiaolu Wei Yan Liu Wei Li Wei Liu Ahmed Waqas Caixia Wang Zuguang Ye Guangping Zhang Hongping Hou 

机构地区：[1]Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,China [2]School of Pharmaceutical Sciences(Shenzhen),Sun Yat-sen University,Shenzhen,China [3]State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou,China [4]Islamabad Medical and Dental College/Akbar Niazi Teaching Hospital,Islamabad,Pakistan

出　　处：《Science of Traditional Chinese Medicine》2024年第2期104-120,共17页中医药科学（英文）

基　　金：supported by National Natural Science Foundation of China(no.82104502);Scientific and technological innovation project of China Academy of Chinese Medical Sciences(no.CI2021B015,CI2021A04615);the Central Public-interest Scientific Institution Basal Research Fund(no.ZZ13-YQ-060,ZXKT21020,ZXKT23006).

摘　　要：Chronic obstructive pulmonary disease(COPD)is a heterogeneous disease with a complex pathogenesis,which causes the lack of precise and personalized prevention,control,and treatment approaches in clinical practice.Traditional Chinese medicine(TCM)with multiple components acting on multiple targets plays a role in the prevention and treatment of COPD.After evaluating the treatment of cough,dyspnea,and lung distension based on syndrome differentiation in TCM,we summarized the commonly used TCMpreparations for treating COPD.These preparations are mainly composed of medicines for clearing interior heat and releasing exterior,tonifying,activating blood and resolving stasis,resolving phlegm,relieving cough and breathlessness,and regulating Qi movement.Because all of them contain a variety of active ingredients such as flavonoids,terpenoids,and phenols,we analyzed the mechanisms of the classic prescriptions alone or in combination with othermedicines or therapeuticmethods.These mechanisms involve counteracting inflammation,oxidative stress,and fibrosis,inhibiting apoptosis,alleviating airway remodeling,and enhancing immunity.Meantime,we summarized the existing problems in the treatment of COPD by TCM.This review provides a scientific basis for the research and treatment of COPD in the future.

关 键 词：Traditional Chinese medicine Chronic obstructive pulmonary disease HETEROGENEITY Classic prescription 

分 类 号：R276.7[医药卫生—中医五官科学] G353.1[医药卫生—中医学]