原发性食管小细胞癌临床特点及预后生存分析  

Clinical Characteristics and Prognosis of Primary Esophageal Small Cell Carcinoma

作　　者：全敏 唐嘉源 陈红 QUAN Min;TANG Jiayuan;CHEN Hong(School of Medical and Life Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Department of Integrated Chinese and Western Medicine,Sichuan Clinical Research Center for Cancer,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,Affiliated Cancer Hospital of University of Electronic Science and Technology of China,Chengdu 610042,China)

机构地区：[1]成都中医药大学医学与生命科学学院,成都611137 [2]四川省肿瘤临床医学研究中心,四川省肿瘤医院&研究所,四川省癌症防治中心,电子科技大学附属肿瘤医院中西医结合科,成都610042

出　　处：《肿瘤防治研究》2024年第12期1021-1027,共7页Cancer Research on Prevention and Treatment

基　　金：四川省中医药管理局科技研究专项课题(2021MS399)。

摘　　要：目的探讨局限期(LD)与广泛期(ED)原发性食管小细胞癌(PESCC)患者的临床特点及预后影响因素。方法回顾性整理72例PESCC患者临床资料和随访信息。采用卡方检验比较LD与ED患者基线资料,Kaplan-Meier方法绘制二者生存曲线,组间生存率比较采用Log-rank检验。单因素和多因素Cox回归方法分析影响LD与ED患者总生存期的因素。结果49例LD患者和23例ED患者纳入本研究。LD与ED患者的中位生存期分别为18.300月与10.903月(P=0.029)。总蛋白值(TP)(HR=0.890,95%CI:0.805~0.983,P=0.022)及化疗周期数(HR=0.388,95%CI:0.187~0.807,P=0.011)是LD患者预后独立影响因素;全身免疫炎症指数(SII)(HR=1.002,95%CI:1.000~1.004,P=0.007)与C反应蛋白值(CRP)(HR=1.065,95%CI:1.021~1.111,P=0.004)是ED患者预后独立影响因素。结论PESCC恶性程度高,预后差。LD与ED的患者预后影响因素不同。总蛋白值及化疗周期是LD PESCC患者预后独立影响因素;全身免疫炎症指数及C反应蛋白值是ED PESCC患者预后独立影响因素。Objective To investigate the clinical characteristics and prognostic factors of the limited-stage disease(LD)and extensive-stage disease(ED)of primary esophageal small cell carcinoma(PESCC).Methods The clinical data and follow-up information of 72 patients with PESCC were retrospectively analyzed.Chi-square test was used to compare the baseline data of patients with LD and ED,Kaplan-Meier method was employed to draw the survival curve of both groups,and Log-rank test was employed to compare survival rates between groups.Univariate and multivariate Cox regression methods were used to analyze the factors affecting the overall survival(OS)of patients with LD and ED.Results A total of 49 patients with LD and 23 patients with ED were included in this study.The median survival time of patients with LD was 18.300 months and that of patients with ED was 10.903 months(P=0.029).Total protein(TP)value(HR=0.890,95%CI:0.805−0.983,P=0.022)and chemotherapy cycle number(HR=0.388,95%CI:0.187−0.807,P=0.011)were independent prognostic factors of patients with LD.Systemic immune-inflammation index(SII)(HR=1.002,95%CI:1.000−1.004,P=0.007)and C-reactive protein(CRP)(HR=1.065,95%CI:1.021−1.111,P=0.004)were independent prognostic factors of patients with ED.Conclusion The malignant degree of PESCC is high,and prognosis is poor.Patients with LD and ED have different prognostic factors.Total protein value and chemotherapy cycle are independent prognostic factors of patients with LD.SII and CRP are independent prognostic factors of patients with ED.

关 键 词：原发性食管小细胞癌 局限期 广泛期 预后 

分 类 号：R735.1[医药卫生—肿瘤]