miR-21在乳腺癌中的作用机制及研究进展  

Mechanism and Research Progress of miR-21 in Breast Cancer

作　　者：王锐 王玉凤[1,2] 关泉林[1,3] WANG Rui;WANG Yufeng;GUAN Quanlin(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Breast Disease,Gansu Provincial Cancer Hospital,Lanzhou 730000,China;Department of Oncology Surgery,First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]甘肃省肿瘤医院乳腺内科,兰州730000 [3]兰州大学第一医院肿瘤外科,兰州730000

出　　处：《肿瘤防治研究》2024年第12期1051-1056,共6页Cancer Research on Prevention and Treatment

基　　金：国家重点研发计划(2017YFC0908302)。

摘　　要：乳腺癌作为一种高度异质性疾病,其新发及死亡病例均居女性恶性肿瘤首位,近年来,乳腺癌发病率呈上升趋势并趋于年轻化,且年龄轻(<40岁)多与乳腺癌不良生物学特征及较差的预后相关。尽管免疫治疗及靶向治疗在乳腺癌治疗中取得了一系列进展,但目前乳腺癌治疗仍面临着肿瘤对全身治疗新生耐药这一重大挑战,迫切需要寻找特异度及敏感度高的早期诊断标志物和潜在的治疗靶点。miR-21通过靶向相关基因、调节相关信号通路(PTEN/PI3K/Akt和NF-κB/miR-21-5p/PDCD4信号通路)来影响乳腺癌的发生发展,本文就此进行综述。As a highly heterogeneous disease,breast cancer ranks first in new cases and deaths of female malignant tumors.In recent years,the incidence of breast cancer increases and tends to be younger.Earlyonset breast cancer(<40 years old)is mostly associated with adverse biological characteristics and poor prognosis.Although immunotherapy and targeted therapy have advances in the treatment of breast cancer,a major challenge of neoplastic resistance to systemic therapy remains.Therefore,early diagnostic markers and potential therapeutic targets with high specificity and sensitivity must be identified.miR-21 affects the occurrence and development of breast cancer by targeting related genes and regulating related signaling pathways(PTEN/PI3K/Akt and NF-κB/miR-21-5p/PDCD4 signaling pathways).This paper reviews the mechanism and progress of miR-21 in breast cancer.

关 键 词：乳腺癌 MIR-21 MICRORNAS 信号通路 PTEN PDCD4 

分 类 号：R73[医药卫生—肿瘤] R737.9[医药卫生—临床医学]