重复经颅磁刺激治疗抑郁症伴睡眠障碍的效果观察  

Effects of Repetitive Transcranial Magnetic Stimulation in the Treatment of Depression with Sleep Disorders

作　　者：裴碧丽 廖爱红 洪宝华 PEI Bili;LIAO Aihong;HONG Baohua(Third Hospital of Quanzhou,Quanzhou 362122,China)

机构地区：[1]泉州市第三医院,泉州362122

出　　处：《世界睡眠医学杂志》2024年第10期2358-2361,共4页World Journal of Sleep Medicine

摘　　要：目的:观察重复经颅磁刺激治疗抑郁症伴睡眠障碍的治疗效果。方法:选取2023年6月至2024年6月泉州市第三医院收治的抑郁症伴睡眠障碍患者90例作为研究对象,按照随机数字表法分为对照组和观察组,每组45例。对照组采用艾司西酞普兰治疗,观察组采用艾司西酞普兰治疗+重复经颅磁刺激治疗。对比2组治疗前及治疗4周抑郁症状[17项汉密尔顿抑郁量表(HAMD-17)、抑郁自评量表(SDS)]、睡眠障碍[匹兹堡睡眠质量指数(PSQI)、失眠量表(AIS)]情况、睡眠状况[多导睡眠监测(PSG)]情况,统计2组治疗期间不良反应情况。结果:治疗前2组HAMD-17、SDS、PSQI、AIS量表评分及PSG各指标值差异无统计学意义(P>0.05);治疗4周,2组HAMD-17、SDS较治疗前降低且观察组低于对照组;2组PSQI、AIS较治疗前降低且观察组低于对照组;2组PSG睡眠时长、睡眠效率较治疗前升高且观察组高于对照组;2组PSG睡眠潜伏期、觉醒时长较治疗前降低且观察组低于对照组,差异有统计学意义(P<0.05);2组不良反应发生率差异无统计学意义(P>0.05)。结论:对抑郁症伴睡眠障碍患者应用重复经颅磁刺激干预能够改善抑郁症状,缓解睡眠障碍,提高睡眠质量,且不会增加安全性风险,有推广价值。Objective:To observe the therapeutic effect of the repetitive transcranial magnetic stimulation in treating depression associated with sleep disorders.Methods:Ninety depression patients with sleep disorder in the Third Hospital of Quanzhou from June 2023 to June 2024 were divided into two groups by random number table:the control group(n=45,escitalopram citalopram treatment)and the observation group(n=45,escitalopram citalopram treatment+repetitive transcranial magnetic stimulation).The depressive symptoms(17-item Hamilton Depression Scale-HAMD-17,Self-rating Depression Scale-SDS),sleep disorders(Pittsburgh sleep Quality index-PSQI,Insomnia Scale-AIS)and sleep status(polysomnography)were compared between the two groups,and the adverse reactions of the two groups during treatment were statistically analyzed.Results:Before treatment,there was no significant difference in the scores of HAMD-17,SDS,PSQI,AIS and PSG between the two groups(P>0.05).After 4 weeks of treatment,the HAMD-17 and SDS in the two groups were lower and the indexes in observation group were lower than those in the control group.The sleep duration and sleep efficiency of the two groups were higher and the indexes in observation group were higher than those in the control group.The sleep latency and awakening time of PSG in the two groups were lower,and the observation group was lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Transcranial magnetic stimulation can improve depressive symptoms in patients with depression and sleep disorder,ease sleep disorders,improve the quality of sleep,and do not increase the risk of security.

关 键 词：重复经颅磁刺激 抑郁症 神经性疾病 睡眠障碍 多导睡眠监测 失眠 不良反应 症状 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R740[医药卫生—临床医学]