银丹心脑通软胶囊联合rt-PA对缺血性脑卒中患者认知功能及血脂的影响  

The Effect of Yindan Xinnaotong Soft Capsule Combined with rt-PA on Cognitive Function and Blood Lipids in Patients with Ischemic Stroke

作　　者：付小宁 许文丽 FU Xiao-ning;XU Wen-li(Department of Brain Disease,Xixiang County Traditional Chinese Medicine Hospital,Hanzhong Shaanxi,723500,China)

机构地区：[1]西乡县中医医院脑病科,陕西汉中723500

出　　处：《中华养生保健》2024年第23期31-35,共5页CHINESE HEALTH CARE

摘　　要：目的观察银丹心脑通软胶囊联合重组人组织型纤溶酶原激活物(rt-PA)静脉溶栓对缺血性脑卒中患者整体获益水平的影响。方法选择2022年1月—2023年12月西乡县中医医院收治的100例缺血性脑卒中患者为研究对象,采用随机数表法分为对照组和联合组,每组50例。对照组开展rt-PA静脉溶栓治疗,联合组在对照组基础上联合银丹心脑通软胶囊治疗,对比临床疗效、神经功能恢复情况[美国国立卫生院脑卒中量表(NIHSS)、改良Rankin量表(mRs)]、血液流变学、血脂[三酰甘油(TG)、总胆固醇(TC),全血黏度(WBV)与红细胞沉降率(ESR)]、氧化应激[血清一氧化氮(NO)、丙二醛(MDA)]情况。结果联合组治疗效果优于对照组,差异有统计学意义(P<0.05);治疗前,两组NHISS与mRs评分比较,差异无统计学意义(P>0.05),治疗后,两组NHISS与mRs评分均下降,且联合组NHISS与mRs评分下降幅度大于对照组,差异有统计学意义(P<0.05);治疗前,两组TC、TG、WBV、ESR表达比较,差异均无统计学意义(P>0.05),治疗后,两组TC、TG、WBV表达下降、ESR表达升高,且联合组TC、TG、WBV下降幅度与ESR升高幅度均大于对照组,差异均有统计学意义(P<0.05);治疗前,两组MDA、NO水平比较,差异均无统计学意义(P>0.05),治疗后,两组NO水平下降、MDA水平升高,且联合组NO水平下降幅度与MDA水平升高幅度均大于对照组,差异均有统计学意义(P<0.05)。结论缺血性脑卒中患者在rt-PA治疗基础上联合银丹心脑通软胶囊,治疗效果更佳,患者神经功能恢复更彻底,且利于改善患者血脂、血液流变学及氧化应激反应。Objective To observe the effect of Yindan Xinnaotong soft capsule combined with recombinant tissue-type plasminogen activator(rt-PA)intravenous thrombolysis on the overall benefi t level of patients with ischemic stroke.Methods Study sample source:100 ischaemic stroke patients admitted to the Department of Neurology of Xixiang County Hospital of Traditional Chinese Medicine,sample selection time:between January 2022 and December 2023 period.The enrolled patients were divided into two groups using the random number table method,50 cases in the control group,in which rt-PA intravenous thrombolytic therapy was carried out,and 50 cases in the combined group,in which the patients in the group were combined with Yindan Xinguintong soft capsule therapy on the basis of the control group,to compare the clinical effi cacy,the recovery of neurological function[Stroke Scale(NIHSS),Modifi ed Rankin Scale(mRs)],haemato-rheology,blood lipids[triacylglycerol(TG),total body fat(TG),total body fat(TG)and blood lipid[triacylglycerol(TG),and total body fat(TL)].glycerol(TG),total cholesterol(TC),whole blood viscosity(WBV)and erythrocyte sedimentation rate(ESR)],oxidative stress[serum nitric oxide(NO),malondialdehyde(MDA)].Results The treatment eff ect of the combined group was better than that of the control group,and the diff erence was statistically signifi cant(P<0.05);there was no statistical diff erence between the scores of NHISS and mRs before treatment in the two groups(P>0.05).After treatment,the scores of NHISS and mRs in the combined group decreased signifi cantly,with statistical diff erence(P<0.05).There was no statistical diff erence in the expressions of TC,TG,WBV and ESR between the two groups before treatment(P>0.05).After treatment,the expressions of TC,TG and WBV in the two groups decreased,while the expressions of ESR increased.Moreover,the decreases of TC,TG and WBV in the combined group were larger than those in the control group,and the diff erences were statistically signifi cant(P<0.05),comparison of MDA and

关 键 词：缺血性脑卒中 重组人组织型纤溶酶原激活物 银丹心脑通软胶囊 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]