视频脑电图用于生酮饮食治疗癫痫患儿中的临床效果研究  

Clinical Study on the Effect of Video Electroencephalogram in the Treatment of Epilepsy in Children with Ketogenic Diet

作　　者：张丽梅 苏文理[1] 纪家镛[1] 刘尧斌[1] 叶剑鹏[1] 唐瑾[1] 苏灿斌[1] ZHANG Li-mei;SU Wen-li;JI Jia-yong;LIU Yao-bin;YE Jian-peng;TANG Jin;SU Can-bin(Myoelectroencephalography Room of Sanming Integrated Traditional Chinese and Western Medicine Hospital,Fujian Sanming 365001)

机构地区：[1]三明市中西医结合医院肌脑电图室,福建三明365001

出　　处：《中国医疗器械信息》2024年第24期143-145,共3页China Medical Device Information

摘　　要：目的:探究视频脑电图在生酮饮食治疗癫痫患儿中的临床效果。方法:本次纳入72例患儿,时间2020年1月~2023年2月,经随机投掷法分为对照组(给予生酮饮食治疗)与观察组(给予视频脑电图联合生酮饮食治疗),比较两组临床指标变化、血脂、血管内皮功能以及不良反应发生率。结果:观察组发作频次、使用药物种类、血尿铜水平均低于对照组(P<0.05);治疗前,两组血脂水平均无差异性(P>0.05);治疗后,两组TG、TC、HDL水平值对比无差异(P>0.05),观察组LDL水平值低于对照组(P<0.05);治疗前后,两组血管内皮功能相关指标比较均无差异性(P>0.05);观察组不良反应发生率5.56%低于对照组的22.22%(P<0.05)。结论:在生酮饮食治疗癫痫患儿中应用视频脑电图,不仅可减少发作频次,还可减少药物种类,降低血尿铜水平,提升预后,同时不损伤血管内皮功能,且降低动脉粥样硬化风险,以及降低不良反应,进一步提升安全性。Objective:To explore the clinical effect of video electroencephalogram in the treatment of epilepsy in children with ketogenic diet.Methods:This study included 72 pediatric patients from January 2020 to February 2023.They were randomly divided into a control group(treated with ketogenic diet)and an observation group(treated with video electroencephalogram combined with ketogenic diet)using a throwing method.The changes in clinical indicators,blood lipids,endothelial function,and incidence of adverse reactions were compared between the two groups.Results:The frequency of seizures,types of medication used,and average blood and urine copper levels in the observation group were lower than those in the control group(P<0.05);Before treatment,there was no significant difference in blood lipid levels between the two groups(P>0.05);After treatment,there was no significant difference in the levels of TG,TC,and HDL between the two groups(P>0.05),and the LDL level in the observation group was lower than that in the control group(P<0.05);There was no significant difference in endothelial function related indicators between the two groups before and after treatment(P>0.05);The incidence of adverse reactions in the observation group was 5.56%lower than that in the control group(22.22%)(P<0.05).Conclusion:The application of video computer graphics in ketogenic diet treatment of epileptic children can not only reduce the frequency of seizures,but also reduce the types of drugs,reduce the level of copper in blood and urine,improve the prognosis,while not damaging the vascular endothelial function,reduce the risk of atherosclerosis,and reduce adverse reactions,further improving the safety.

关 键 词：血尿铜 血脂 生酮饮食 癫痫 不良反应 发生率 

分 类 号：R742.1[医药卫生—神经病学与精神病学]