阿立哌唑结合心理、康复疗法治疗难治性精神分裂症的价值探讨  

Exploration of the Value of Aripiprazole Combined with Psychotherapy and Rehabilitation Therapy in the Treatment of Treatment-resistant Schizophrenia

作　　者：黄小泽 陈美玲[1] 杨晓江[1] HUANG Xiaoze;CHEN Meiing;YANG Xiaojiang(Department of Psychology,Quanzhou Third Hospital,Quanzhou,Fujian,362100,China)

机构地区：[1]泉州市第三医院心理科,福建泉州362100

出　　处：《中外医疗》2024年第34期86-89,共4页China & Foreign Medical Treatment

摘　　要：目的探讨难治性精神分裂症(treatment-resistant schizophrenia,TRS)采用阿立哌唑结合心理、康复疗法治疗的价值。方法方便选取2021年10月—2024年1月泉州市第三医院收治的96例TRS患者为研究对象,根据不同治疗方法分为研究组(n=48)与对照组(n=48),两组均给予心理、康复疗法,对照组在此基础上采用氯氮平治疗,研究组在此基础上采用阿立哌唑治疗。比较两组的临床疗效、症状改善情况、不良反应发生情况。结果研究组治疗总有效率为97.92%(47/48),高于对照组的81.25%(39/48),差异有统计学意义(χ^(2)=5.470;P<0.05)。治疗后,两组阳性和阴性症状量表评分均下降,且研究组分数低于对照组,差异有统计学意义(P均<0.05)。研究组不良反应总发生率为12.50%(6/48)与对照组的18.75%(9/48)比较,差异无统计学意义(χ^(2)=0.711;P>0.05)。结论阿立哌唑结合心理、康复疗法治疗TRS,能够提高临床治疗疗效,改善患者精神症状,安全性较高。Objective To explore the value of aripiprazole combined with psychological and rehabilitation therapy in the treatment of treatment-resistant schizophrenia(TRS).Methods A total of 96 patients with TRS admitted to Quan-zhou Third Hospital from October 2021 to January 2024 were conveniently selected as the research objects.According to different treatment methods,they were divided into study group(n=48)and control group(n=48).Both groups were given psychological and rehabilitation therapy.The control group was treated with clozapine on this basis,and the study group was treated with aripiprazole on this basis.The clinical efficacy,symptom improvement and adverse reac-tions were compared between the two groups.Results The total effective rate of treatment in the study group was 97.92%(47/48),which was higher than 81.25%(39/48)in the control group,and the difference was statistically sig-nificant(χ^(2)=5.470;P<0.05).After treatment,the Positive and Negative Symptom Scale scores of the two groups de-creased,and the scores of the study group were lower than those of the control group,the differences were statistically significant(all P<0.05).The total incidence of adverse reactions in the study group was 12.50%(6/48)compared with 18.75%(9/48)in the control group,the difference was not statistically significant(χ^(2)=0.711;P>0.05).Conclusion Ar-ipiprazole combined with psychological and rehabilitation therapy in the treatment of TRS can improve the clinical ef-ficacy,improve the mental symptoms of patients,and has high safety.

关 键 词：难治性精神分裂症 阿立哌唑 心理疗法 康复疗法 

分 类 号：R749.3[医药卫生—神经病学与精神病学]