血清zonulin和Omentin-1与溃疡性结肠炎患者病情严重程度及预后的关系  

Relationship between serum levels of zonulin and Omentin-1 and the severity and prognosis of ulcerative colitis in patients

作　　者：陈伟丽 史利斌 王艳 祖喆 高文侠 刘尧[5] 王建桥 于倩 CHEN Weili;SHI Libin;WANG Yan;ZU Zhe;GAO Wenxia;LIU Yao;WANG Jianqiao;YU Qian(Department of Anorectal,Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000,China;Department of Ultrasound,Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000,China;Department of Pharmacy,Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000,China;Department of Oncology,Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000,China;Department of Pharmacy,Kailuan General Hospital,Tangshan 063000,China;Department of Internal Medicine,Qianxi Hospital of Traditional Chinese Medicine,Tangshan 064300,China)

机构地区：[1]唐山市中医医院肛肠科,063000 [2]唐山市中医医院超声科,063000 [3]唐山市中医医院药剂科,063000 [4]唐山市中医医院肿瘤科,063000 [5]开滦总医院药剂科,河北唐山063000 [6]迁西县中医院内科,河北唐山064300

出　　处：《国际消化病杂志》2024年第6期376-380,386,共6页International Journal of Digestive Diseases

基　　金：河北省中医药类科学研究课题计划项目(2023196)。

摘　　要：目的 探讨血清连蛋白(zonulin)和网膜素-1(Omentin-1)与溃疡性结肠炎(UC)患者病情严重程度及预后的关系。方法 选择2020年9月至2022年12月在唐山市中医医院就诊的93例活动期UC患者设为UC组,并根据病情严重程度将UC患者分为轻度UC组(n=38)、中度UC组(n=33)和重度UC组(n=22),根据预后情况分为预后良好组(n=61)和预后不良组(n=32)。另选择同期来该院的90名健康体检者设为对照组。采用ELISA法检测各组的血清zonulin和Omentin-1水平。采用ROC曲线分析血清zonulin和Omentin-1对UC患者预后不良的预测价值。采用多因素logistic回归分析探讨UC患者预后不良的影响因素。结果 UC组的血清zonulin水平显著高于对照组,血清Omentin-1水平显著低于对照组(P均<0.05)。重度UC组的血清zonulin水平分别显著高于中度UC组和轻度UC组,血清Omentin-1分别显著低于中度UC组和轻度UC组(P均<0.05);中度UC组的血清zonulin水平显著高于轻度UC组,血清Omentin-1水平显著低于轻度UC组(P均<0.05)。预后不良组的血清zonulin和C反应蛋白(CRP)水平均显著高于预后良好组,血清Omentin-1水平显著低于预后良好组(P均<0.05)。血清zonulin、Omentin-1单独及联合预测UC患者预后不良的AUC分别为0.779、0.775和0.877。血清zonulin是UC患者预后不良的危险因素,而血清Omentin-1则是UC患者预后不良的保护因素(P均<0.05)。结论 血清zonulin和Omentin-1与UC患者的病情严重程度及预后均密切相关,两者均有潜力作为UC患者病情评估及预后预测的标志物。Objective This paper intends to explore the relationship between serum levels of zonulin and Omentin-1 and the severity and prognosis of ulcerative colitis(UC)in patients.Methods A total of 93 active UC patients treated at Tangshan Hospital of Traditional Chinese Medicine from September 2020 to December 2022 were selected as the UC group.These patients were divided into the mild group(n=38),the moderate group(n=33),and the severe group(n=22)based on the severity of disease.They were further divided into a good prognosis group(n=61)and a poor prognosis group(n=32)based on prognosis.Additionally,90 healthy individuals who visited the hospital during the same period were selected as the control group.ELISA method was used to detect the levels of serum zonulin and Omentin-1 in each group.ROC curve analysis was performed to assess the predictive value of serum zonulin and Omentin-1 for poor prognosis in UC patients.Multiple logistic regression analysis was conducted to explore factors influencing poor prognosis in UC patients.Results The serum zonulin level in the UC group is significantly higher than that in the control group,while the serum Omentin-1 level is significantly lower(P<0.05).The serum zonulin level in the severe group are significantly higher than those in the moderate and mild groups,while the serum Omentin-1 level is significantly lower(P<0.05).The serum levels of zonulin and C-reactive protein(CRP)in the poor prognosis group are significantly higher than those in the good prognosis group,while the serum level of Omentin-1 is significantly lower(P<0.05).The AUC for serum zonulin and Omentin-1,and their combination in predicting poor prognosis in UC patients are 0.779,0.775,and 0.877,respectively.Serum zonulin is identified as a risk factor for poor prognosis in UC patients,while serum Omentin-1 is a protective factor(P<0.05).Conclusion Serum levels of zonulin and Omentin-1 are closely related to the severity and prognosis of UC patients.Both biomarkers have potential in evaluating the condition and pre

关 键 词：溃疡性结肠炎 连蛋白 血清网膜素-1 病情严重程度 预后 

分 类 号：R574.62[医药卫生—消化系统]