结直肠癌中胶原蛋白作用的研究进展  

Research progress on the role of collagen in colorectal cancer

作　　者：王树琤 杨凌[1,2] Wang Shucheng;Yang Ling(Research Center for Clinical Medicine,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Inner Mongolia Key Laboratory of Medical Cell Biology,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院临床医学研究中心,呼和浩特010050 [2]内蒙古自治区医学细胞生物学重点实验室,呼和浩特010050

出　　处：《中国组织化学与细胞化学杂志》2024年第3期275-282,共8页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金(82360551);内蒙古自然科学基金(2022LHMS03011);内蒙古医科大学面上项目(YKD2021MS046);内蒙古医科大学致远人才计划(ZY0120025)。

摘　　要：结直肠癌(colorectal cancer,CRC)是常见的消化道恶性肿瘤,其发病率和死亡率逐年升高。胶原蛋白属于一种生物高分子,为哺乳动物结缔组织中重要的纤维蛋白,约占人体总蛋白质的1/4~1/3。在结直肠肿瘤中,癌细胞会不断侵袭和突破基底膜,从而转移到临近及远处器官。而胶原作为肿瘤基质的主要成分,与结直肠肿瘤的癌细胞的侵袭、转移密切相关。本文对胶原蛋白的结构和一般特征、胶原蛋白的重塑、胶原蛋白与肿瘤血管生成、胶原蛋白与免疫反应以及胶原蛋白与结直肠癌转移进行综述。Colorectal cancer is a common malignant tumor of the digestive tract,and its morbidity and mortality rates are increasing year by year.Collagen is a biological macromolecule and an important fibrous protein in mammalian connective tissue,accounting for about one-quarter to one-third of the total protein in the human body.In colorectal tumors,cancer cells continuously invade and break through the basement membrane,thereby metastasizing to nearby and distant organs.Collagen,as the main component of tumor matrix,is closely related to the invasion and metastasis of cancer cells in colorectal tumors.This article reviews the structure and general characteristics of collagen,collagen remodeling,collagen and tumor angiogenesis,collagen and immune response,and collagen and colorectal cancer metastasis.

关 键 词：胶原蛋白 结直肠癌 肿瘤血管生成 免疫反应 转移 

分 类 号：R735.3[医药卫生—肿瘤]