PGC-1α在缺血性脑卒中的神经保护机制  

The neuroprotective mechanisms of PGC-1αin ischemic stroke

作　　者：包伟伟 侯雨函 彭晓云 罗文君 田甜[4] 朱玲桂 王金海[4] Bao Weiwei;Hou Yuhan;Peng Xiaoyun;Luo Wenjun;Tian Tian;Zhu Linggui;Wang Jinhai(School of Traditional Chinese and Western Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;The Second Clinical School of Medicine,Lanzhou University Second Hospital,Lanzhou 73003,China;Department of Rehabilitation,Lanzhou University Second Hospital,Lanzhou 730030,China;Department of TCM,Lanzhou University Second Hospital,Lanzhou 730030,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]兰州大学第二临床医学院,兰州730030 [3]兰州大学第二医院康复医学科 [4]兰州大学第二医院中医科,兰州730030

出　　处：《中国组织化学与细胞化学杂志》2024年第3期283-288,309,共7页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金项目(82260962);甘肃自然科学基金项目(22JR11RA064)。

摘　　要：缺血性脑卒中的发病机制复杂,涉及多种病理因素共同参与其进展与预后。其中,过氧化物酶体增殖物激活受体γ共激因子(peroxisome proliferator-activated receptorγcoactivator-1α,PGC-1α)作为一种重要的核转录辅助因子,能够有效对抗缺血缺氧引起的损伤,在缺血性脑卒中的病理过程中发挥着关键调控作用。因此,PGC-1α被认为是治疗缺血性脑卒中的潜在重要靶点。本文综述了PGC-1α在缺血性脑卒中神经保护机制中的研究进展,旨在为药物治疗靶点的选择提供理论依据,并为后续深入研究提供科学参考。The pathogenesis of ischemic stroke is complex,involving multiple pathological factors that contribute to its pro-gression and prognosis.Peroxisome proliferator-activated receptorγcoactivator-1α(PGC-1α),a crucial nuclear transcription coacti-vator,effectively counteracts damage caused by ischemia and hypoxia,playing a pivotal regulatory role in ischemic stroke.Therefore,PGC-1αis considered a potential therapeutic target for ischemic stroke.This article reviews the research progress on the neuroprotec-tive mechanisms of PGC-1αin ischemic stroke,aiming to provide a theoretical basis for selecting drug treatment targets and offering a scientific reference for further studies.

关 键 词：过氧化物酶体增殖物激活受体γ共激因子 缺血性脑卒中 氧化应激 炎症 血管修复 

分 类 号：R743.3[医药卫生—神经病学与精神病学]