肿瘤相关巨噬细胞在骨肉瘤中的作用及中药干预  

The role of tumor associated macrophages in osteosarcoma and intervention with traditional Chinese medicine

作　　者：王丽君 李红专[2] 姚亚赛 张效收 刘跃振 Wang Lijun;Li Hongzhuan;Yao Yasai;Zhang Xiaoshou;Liu Yuezheng(Clinical College of Traditional Chinese Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Department of Bone and Soft Tissue Oncology,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学中医临床学院,兰州730000 [2]甘肃省中医院骨与软组织肿瘤科,兰州730000

出　　处：《中国组织化学与细胞化学杂志》2024年第3期296-303,共8页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：肿瘤微环境是恶性肿瘤发生过程中的内在环境,其中肿瘤相关巨噬细胞作为最丰富的免疫细胞之一,约占免疫细胞总数的50%以上,分为具有抗肿瘤活性的M1型和促进肿瘤生长的M2型。肿瘤相关巨噬细胞的浸润与骨肉瘤的转移及生长密切相关。本文综述了肿瘤相关巨噬细胞在骨肉瘤中的作用机制,指出其通过表观遗传学机制、血管生成及肿瘤免疫逃逸等途径促进肿瘤的增殖、侵袭、转移及耐药,并总结了中医药通过调节肿瘤相关巨噬细胞表型逆转的潜在靶点.The tumor microenvironment is the intrinsic environment during the development of malignant tumors.Among its components,tumor-associated macrophages(TAMs)are one of the most abundant immune cells,constituting over 50%of the total immune cell population.TAMs can be classified into M1 type with anti-tumor activity and M2 type that promotes tumor growth.The infiltration of TAMs is closely related to the metastasis and growth of osteosarcoma(OS).This article reviews the mechanisms by which TAMs contribute to OS,highlighting their roles in promoting tumor proliferation,invasion,metastasis,and resistance through epigenetic mechanisms,angiogenesis,and tumor immune evasion.Additionally,it summarizes potential targets for the reversal of TAM phenotypes through traditional Chinese medicine,aiming to provide new strategies for OS treatment.

关 键 词：骨肉瘤 肿瘤微环境 肿瘤相关巨噬细胞 中医药 

分 类 号：R365[医药卫生—病理学]