2型糖尿病对乳腺癌无复发生存期的影响分析  

Impact of Type 2 Diabetes on Disease-Free Survival in Breast Cancer Patients

作　　者：周文考 王娅 赵方俐 黄何森 黄灵炎 王明山 唐慧敏 Zhou Wenkao;Wang Ya;Zhao Fangli;Huang Hesen;Huang Lingyan;Wang Mingshan;Tang Huimin(Emergency Medicine Department of Xiang’an Hospital of Xiamen University,xiamen 361001;Breast Surgery of First Affiliated Hospital of Dalian Medical University,dalian 116000;Cancer Center and Department of Breast and Thyroid Surgery,Xiang’an Hospital of Xiamen University,Xiamen Key Laboratory of Endocrine-Related Cancer Precision Medicine,Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer(Xiang'an Hospital of Xiamen University),xiamen 361001)

机构地区：[1]厦门大学附属翔安医院,福建厦门361001 [2]厦门大学附属翔安医院肿瘤诊治中心与乳腺甲状腺外科,厦门市乳甲肿瘤临床医学研究中心,厦门市内分泌肿瘤精准诊治重点实验室,福建省乳腺癌精准诊治重点实验室,福建厦门361001 [3]大连医科大学附属第一医院乳腺外科,辽宁大连116000

出　　处：《青岛医药卫生》2024年第5期364-369,共6页Qingdao Medical Journal

基　　金：厦门市医疗卫生指导性项目(3502Z20224ZD1147)。

摘　　要：目的 对本中心912例乳腺癌患者复发数据进行分析,找出影响乳腺癌无复发生存的危险因素。方法 研究纳入2010年1月~2016年12月于大连医科大学附属第一医院收治的912名乳腺癌患者。年龄在24-87岁之间,平均(54.81±11.63)岁。合并T2DM患者202人,未合并T2DM患者710人。至随访结束时复发88人,未发生复发824人。单因素和多因素COX回归分析找出影响乳腺癌无复发生存的危险因素。Kaplan-Meier进行生存曲线绘制,Wilcoxon和Logrank检验评价生存曲线间差异。结果 单因素Cox回归分析结果表明,Age、T2DM、Breast treatment、Armpit treatment、T stage、N stage、molecular type、ER1、ER2和PR是乳腺癌复发生存时间的危险因素(p<0.05)。高年龄、合并T2DM、肿瘤≥2cm、腋窝淋巴结转移≥4枚和ER>10%是影响乳腺癌术后复发时间的独立危险因素(p<0.05)。T2DM等因素绘制的生存曲线在组间具有显著性差异(p<0.05)。结论 T2DM是影响乳腺癌无复发生存的重要因素,早期发现和治疗对其预后具有重要作用。Objective To analyze recurrence data from 912 breast cancer patients at our center and identify Influencing factors affecting disease-free survival in breast cancer.Methods The study included 912 breast cancer patients treated at the First Affiliated Hospital of Dalian Medical Uni-versity from January 2010 to December 2016.Patients'ages ranged from 24 to 87 years,with an average age of 54.81±11.63 years.There were 202 patients with T2DM and 710 without T2DM.By the end of follow-up,88 patients had experienced recurrence,while 824 had not.Uni-variate and multivariate Cox regression analyses were used to identify risk factors affecting disease-free survival in breast cancer.Kaplan-Meier survival curves were plotted,and Wilcoxon and Logrank tests were used to evaluate differences between survival curves.Results Uni-variate Cox regres-sion analysis indicated that age,T2DM,breast treatment,armpit treatment,T stage,N stage,molecular type,ER1,ER2,and PR were risk factors for breast cancer recurrence survival time(p<0.05).Higher age,T2DM,tumor size≥2 cm,axillary lymph node metastasis≥4 nodes,and ER>10%were independent risk factors affecting post-operative recurrence time in breast cancer(p<0.05).Survival curves plotted for factors such as T2DM showed significant differ-ences between groups(p<0.05).Conclusion T2DM is an important factor affecting disease-free survival in breast cancer.Early detection and treatment are crucial for improving prognosis.

关 键 词：乳腺癌 2型糖尿病 无复发生存期 临床病理资料 

分 类 号：R737.9[医药卫生—肿瘤]