团体运动治疗改善急性期轻中度抑郁障碍患者睡眠质量的效果  

Effect of group exercise therapy on improving sleep quality in patients with mild to moderate depressive disorder during the acute phase

作　　者：李睿楠 郭建军[3] 刘文洋 乔羽 田璐[1,2] 贾盛陶[1,2] 周晶晶 Li Ruinan;Guo Jianjun;Liu Wenyang;Qiao Yu;Tian Lu;Jia Shengtao;Zhou Jingjing(Beijing Key Laboratory of Mental Disorders,National Clinical Research Center for Mental Disorders&National Center for Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China;Capital University of Physical Education And Sports,Beijing 100191,China)

机构地区：[1]首都医科大学附属北京安定医院,国家精神疾病医学中心,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京100088 [2]人脑保护高精尖创新中心,首都医科大学,北京100069 [3]首都体育学院,北京100191

出　　处：《四川精神卫生》2024年第6期492-496,共5页Sichuan Mental Health

基　　金：国家重点研发计划项目(项目名称:基于客观指标和量化评价的抑郁障碍诊疗适宜技术研究,项目编号:2016YFC1307200);北京市属医院科研培育计划项目(项目名称:数字运动干预附加治疗对抑郁症残留症状的随机双盲对照研究,项目编号:PX2024070)。

摘　　要：背景 抑郁障碍患者普遍存在睡眠障碍,既往研究表明,团体运动治疗有助于改善抑郁障碍患者的抑郁症状,但尚缺少团体运动治疗对改善抑郁障碍患者睡眠质量的研究。目的 探讨团体运动治疗对急性期轻中度抑郁障碍患者睡眠质量的影响,为临床改善急性期轻中度抑郁障碍患者的睡眠质量提供参考。方法 纳入2018年12月—2021年7月在首都医科大学附属北京安定医院门诊就诊、符合《国际疾病分类(第10版)》(ICD-10)抑郁障碍诊断标准的急性期轻中度抑郁障碍患者为研究对象(n=40)。所有患者均接受为期8周、每周3次、每次60 min的团体运动治疗。于基线期、干预2、4、6、8周后,采用视觉模拟量表(VAS)、汉密尔顿抑郁量表17项版(HAMD-17)和匹兹堡睡眠质量指数量表(PSQI)进行评定。将治疗后各时点相对于基线期的各量表评分减分值为因变量,时间为自变量,基线期评分为协变量,时间为固定效应,基线期评分值为随机效应,采用线性混合效应模型进行分析。结果 基线期和干预2、4、6、8周后,患者PSQI评分分别为(10.62±5.12)分、(9.07±3.58)分、(7.39±3.66)分、(6.54±3.84)分、(5.50±3.41)分。线性混合效应模型分析结果显示,干预2、4、6、8周后,患者PSQI评分均低于基线期,差异均有统计学意义(P均<0.01)。基线期和干预2、4、6、8周后,患者HAMD-17睡眠因子评分分别为(2.25±1.56)分、(2.06±1.49)分、(1.36±1.27)分、(1.22±1.46)分、(0.97±1.34)分。线性混合效应模型分析结果显示,干预4、6、8周后,患者HAMD-17睡眠因子评分均低于基线期,差异均有统计学意义(P<0.05或0.01)。基线期和干预2、4、6、8周后,患者VAS评分分别为(3.18±2.17)分、(4.74±2.22)分、(6.01±2.31)分、(6.54±2.16)分、(7.90±1.64)分。线性混合效应模型分析结果显示,干预2、4、6、8周后,VAS评分均高于基线期,差异均有统计学意义(P均<0.01)。结论 团体运动Background Patients with depressive disorder commonly experience sleep disturbances.Previous studies have indicated that group exercise therapy is beneficial in alleviating depressive symptom among patients with depressive disorder.However,there is a lack of research on the impact of group exercise therapy on improving sleep quality in patients with depressive disorder.Objective To explore the impact of group exercise therapy on sleep quality in patients with acute mild-to-moderate depression during the acute phase,so as to provide references for clinically improving the sleep quality of patients with mild to moderate depressive disorder during the acute phase.Methods From December 2018 to July 2021,patients with mild-to-moderate depressive disorder during the acute phase(n=40),who met the diagnostic criteria for depressive disorder according to International Classification of Diseases,tenth edition(ICD-10),were recruited from the outpatient clinic of Beijing Anding Hospital,Capital Medical University.All participants underwent an 8-week moderate-intensity group exercise therapy program comprising three sessions per week,each lasting 60 minutes.Assessments were conducted at baseline and after 2,4,6 and 8 weeks of intervention using Visual Analogue Scale(VAS),Hamilton Depression Scale-17 item(HAMD-17) and Pittsburgh Sleep Quality Index(PSQI).The reduction scores at each time point relative to baseline treated as the dependent variables,time as the independent variable,baseline scores as covariates,with time as a fixed effect and baseline values as random effects.Data were analyzed using a linear mixed-effects model.Results The PSQI scores of patients at baseline,2,4,6 and 8 weeks after the intervention were(10.62±5.12),(9.07±3.58),(7.39±3.66),(6.54±3.84) and(5.50±3.41),respectively.The results of linear mixed effect model analysis showed that after 2,4,6 and 8 weeks of intervention,patients scored lower than baseline,with statistically significant differences observed in all cases(P<0.01).The HAMD-17 sleep fc

关 键 词：团体运动治疗 抑郁症 睡眠质量 

分 类 号：R749.4[医药卫生—神经病学与精神病学]