白蛋白与碱性磷酸酶表达水平及其比值在非酒精性脂肪肝诊断中的价值分析  

Value analysis of the expression levels and ratios of albumin and alkaline phosphatase in the diagnosis of non-alcoholic fatty liver disease

作　　者：曹璐 Cao Lu(Department of Clinical Laboratory,Central Hospital of Shangqiu,Shangqiu 476000,Henan,China)

机构地区：[1]商丘市中心医院检验科,河南商丘476000

出　　处：《四川生理科学杂志》2024年第12期2680-2682,2799,共4页

摘　　要：目的:探讨白蛋白(Albumin,ALB)与碱性磷酸酶(Alkaline phosphatase,ALP)及其比值(Albumin-to-alkaline phosphatase ratio,AAPR)在非酒精性脂肪肝患者中的表达及临床意义。方法:选取2019年1月至2023年5月本院收治的150例脂肪肝患者作为研究对象的观察组,按照是否为非酒精性将患者分为非酒精性脂肪肝组和酒精性脂肪肝组,各75例。选取同期肝功能健康的75例其他患者作为研究对象的对照组。分析比较三组ALB、ALP及AAPR的表达。根据非酒精性脂肪肝严重程度将患者分为轻度、中度和重度3个等级,分析AAPR在非酒精性脂肪肝中的表达及意义。结果:两组脂肪肝患者ALP水平均明显高于对照组,ALB、AAPR水平均明显低于对照组(P<0.05)。非酒精性脂肪肝组患者ALP水平明显高于酒精性脂肪肝组,ALB、AAPR水平均明显低于酒精性脂肪肝组(P<0.05)。本研究中75例非酒精性脂肪肝患者,29例轻度(38.67%)、31例中度(41.33%),15例重度(20.00%)。非酒精性脂肪肝患者重度组和中度组ALP水平明显高于轻度组(P<0.05),ALB、AAPR水平明显低于轻度组(P<0.05);重度组ALP水平明显高于中度组(P<0.05),ALB、AAPR水平明显低于中度组(P<0.05)。AAPR与非酒精性脂肪肝患者病情严重程度呈负相关(r<1,P<0.05)。结论:AAPR在非酒精性脂肪肝患者中异常降低,明显低于酒精性脂肪肝,与患者的病情严重程度呈负相关。Objective:To explore the expression and clinical significance of albumin(ALB)and alkaline phosphatase(ALP)and their ratio(Albumin-to-alkaline phosphatase ratio,AAPR)in non-alcoholic fatty liver patients.Method:A total of 150 patients with fatty liver admitted to our hospital from January 2019 to May 2023 were selected as the observation group for the study.Patients were divided into non-alcoholic fatty liver group and alcoholic fatty liver group based on whether they were non-alcoholic,with 75 cases in each group.75 other patients with healthy liver function during the same period were selected as the control group for the study.The expression of ALB,ALP,and AAPR in three groups were analyzed and compared.According to the severity of non-alcoholic fatty liver,patients were divided into three levels:mild,moderate,and severe,and the expression and significance of AAPR in non-alcoholic fatty liver were analyzed.Result:The ALP levels in both groups of patients with fatty liver were significantly higher than those in the control group,while the ALB and AAPR levels were significantly lower than those in the control group(P<0.05).The ALP levels in patients with non-alcoholic fatty liver were significantly higher than those in the alcoholic fatty liver group,and the levels of ALB and AAPR were significantly lower than those in the alcoholic fatty liver group(P<0.05).In this study,there were 75 patients with non-alcoholic fatty liver,of which 29 were mild(38.67%),31 were moderate(41.33%),and 15 were severe(20.00%).The levels of ALP in the severe and moderate groups of non-alcoholic fatty liver patients were significantly higher than those in the mild group(P<0.05),while the levels of ALB and AAPR were significantly lower than those in the mild group(P<0.05).The ALP levels in the severe group were significantly higher than those in the moderate group(P<0.05),while the ALB and AAPR levels were significantly lower than those in the moderate group(P<0.05).AAPR was negatively correlated with the severity of non-alcoholic fatty

关 键 词：非酒精性脂肪肝 碱性磷酸酶 白蛋白 比值 严重程度 

分 类 号：R575.5[医药卫生—消化系统]