阿立哌唑联合氨磺必利或利培酮对精分患者临床疗效观察分析  

Clinical efficacy of aripiprazole combined with amisulpride or risperidone on patients with schizophrenia

作　　者：童永花 郭玉花 张毓茂 杨邦财 Tong Yong-hua;Guo Yu-hua;Zhang Yu-mao;Yang Bang-cai(The Second Ward(Women's Ward),Department of Psychiatry,Nanping Third Hospital,Nanping 353000,Fujian,China)

机构地区：[1]南平市第三医院精神科二病区(女病区),福建南平353000

出　　处：《四川生理科学杂志》2024年第12期2714-2717,共4页

摘　　要：目的:探讨小剂量氨磺必利与利培酮分别联合阿立哌唑对精神分裂症阳性和阴性症状量表(Positive and negative symptom scales,PANSS)评分、激素水平及心电图指标的影响。方法:选取2023年1月~2024年1月期间我院收治的86例精神分裂症患者作为研究对象,根据随机数字表法分为氨磺必利组和利培酮组,各43例。两组均常规口服阿立哌唑,利培酮组患者在常规用药基础上服用利培酮,氨磺必利组患者在常规用药基础上口服小剂量氨磺必利。比较两组患者临床症状、激素水平、心电图情况以及不良反应。结果:治疗后,氨磺必利组患者阳性和阴性症状量表(Positive and negative symptom scales,PANSS)各维度得分均低于利培酮组(P<0.05);两组患者雌二醇(Estradiol,E2)、睾酮(Testosterone,TESTO)、催乳素(Prolactin,PRL)水平均明显升高(P<0.05),但两组患者治疗后的E2、TESTO水平无明显差异(P>0.05),氨磺必利组PRL明显低于利培酮组(P<0.05)。治疗后,利培酮组校正后Q-T(Corrected Q-T interval,QTC)间期明显延长,心率明显降低(P<0.05);氨磺必利组QTC间期和心率无明显变化(P>0.05);相较于利培酮组,氨磺必利组QTC间期明显较短,心率明显较高(P<0.05);两组患者窦性心律失常、室性早搏、房性早搏、逸搏、传导阻滞发生率无明显差异(P>0.05)。氨磺必利组不良反应总发生率低于利培酮组(P<0.05)。结论:小剂量氨磺必利与利培酮均能够有效缓解精神分裂症患者临床症状,但小剂量氨磺必利疗效更加明显,且对患者体内激素、QTC间期以及心率影响较小,更具安全性。Objective:To investigate the influence of low-dose amisulpride or risperidone combined with aripiprazole on positive and negative symptom scale(PANSS)scores,hormones levels and electrocardiogram indexes of schizophrenia.Methods:Eighty-six patients with schizophrenia in the hospital from January 2023 to January 2024 were selected as the study subjects.According to the random number table method,86 patients were divided into amisulpride group and risperidone group,with 43 cases in each group.Both groups were given conventional oral administration of aripiprazole.Patients in the risperidone group were given risperidone on the basis of conventional medication,while patients in the amisulpride group were given low-dose amisulpride on the basis of conventional medication.The clinical symptoms,hormones levels,electrocardiogram conditions and adverse reactions were compared between groups.Results:After treatment,the scores of dimensions of Positive and Negative Symptom Scale(PANSS)in amisulpride group were lower compared with those in risperidone group(P<0.05).The levels of estradiol(E2),testosterone(TESTO)and prolactin(PRL)in the two groups were obviously increased(P<0.05),but there were no significant differences in the levels of E2 and TESTO between groups after treatment(P>0.05).The PRL in amisulpride group was significantly lower than that in risperidone group(P<0.05).After treatment,the corrected Q-T interval(QTC)in risperidone group was significantly prolonged,and the heart rate was significantly decreased(P<0.05).There were no significant changes in QTC interval and heart rate in amisulpride group(P>0.05).Compared with risperidone group,the QTC interval in amisulpride group was significantly shorter and the heart rate was significantly higher(P<0.05).There were no obvious differences in the incidence rates of sinus arrhythmia,ventricular premature beat,atrial premature beat,escape beat and conduction block between groups(P>0.05).The total incidence rate of adverse reactions was lower in amisulpride group than tha

关 键 词：氨磺必利 利培酮 精神分裂症 PANSS评分 

分 类 号：R749.3[医药卫生—神经病学与精神病学]