牙周致病菌与脑梗死关联机制的研究  

Study on the correlation mechanism between periodontal pathogens and cerebral infarction

作　　者：陈敏哲 常睿 薛逢明 贺小宁 刘丽[2] CHEN Minzhe;CHANG Rui;XUE Fengming;HE Xiaoning;LIU Li(Department of Stomatology,The Second Affiliated Hospital of Hainan Medical University,Haikou 570100,China;Department of Stomatology,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750011,China)

机构地区：[1]海南医科大学第二附属医院口腔科,海南海口570100 [2]宁夏回族自治区人民医院口腔科,宁夏银川750011

出　　处：《海南医学院学报》2024年第24期1913-1920,共8页Journal of Hainan Medical University

基　　金：海南省自然科学基金高层次人才项目(820RC768);宁夏回族自治区科技惠民计划项目(2023CMG03042)。

摘　　要：牙周炎是一种由多种微生物生态失调引起的慢性炎症性疾病,与心血管疾病(cardiovascular disease,CVD)存在关联,可能的生物学机制是牙周炎释放的炎症介质进入血流,引起全身性低度慢性炎症;牙周致病菌与高血压、动脉粥样硬化的发生关系密切,进一步导致脑梗死的发展。牙周致病菌与脑梗死的发生、发展及预后息息相关。本文阐述了牙周炎与脑梗死之间的关系,探讨了牙周致病菌影响脑梗死的可能机制,为牙周炎与心脑血管疾病之间相互作用的进一步研究带来考量。Periodontitis is a chronic inflammatory disease caused by a variety of microbial ecological disorders,which is associated with cardiovascular disease.The possible biological mechanism is that inflammatory mediators released by periodontitis enter the bloodstream and cause systemic low-grade chronic inflammation.Periodontal pathogens are closely related to the occurrence of hypertension and atherosclerosis,which further leads to the development of cerebral infarction.Periodontal pathogens are closely related to the occurrence,development and prognosis of cerebral infarction.This paper describes the relationship between periodontitis and cerebral infarction,and probes into the possible mechanism of periodontal pathogenic bacteria affecting cerebral infarction,which brings consideration to the further study of the interaction between periodontitis and cardiovascular and cerebrovascular diseases.

关 键 词：牙周病 牙周致病菌 动脉粥样硬化 高血压 脑梗死 

分 类 号：R781.4[医药卫生—口腔医学] R743.3[医药卫生—临床医学]