Effect of different pigmented cooked common beans on glucose and lipid metabolism in obese rats and 3T3 L1 cells  

作　　者：Iza F.Pérez-Ramírez Mayra D.Herrera Ofelia Mora Minerva Ramos-Gómez Dania Martínez-Alarcón Rosalía Reynoso-Camacho 

机构地区：[1]Facultad de Química,Universidad Autónoma de Querétaro,Queretaro,76010,Querétaro,Mexico [2]Campo Experimental Zacatecas(CEZAC-INIFAP),Zacatecas,98500,Zacatecas,Mexico [3]Instituto de Neurobiología,Universidad Nacional Autónoma de México,Querétaro,76230,Querétaro,Mexico

出　　处：《Food Bioscience》2023年第3期463-471,共9页食品生物科学（英文）

摘　　要：The effect of Azufrasin(yellow coat seed)and Flor de Junio(FJ)Dalia(pink-cream coat seed)cooked bean varieties was evaluated in high fat and fructose diet-fed rats to identify their health beneficial effects on obesity-related metabolic alterations.FJ Dalia and Azufrasin daily supplementation(10%)for six months decreased body weight(5-7%),serum triglycerides(28.5-36.4%),HOMA insulin resistance index(59.6-62.3%),and serum TNF-α(40.5-45.0%);moreover,FJ Dalia increased serum adiponectin(77.5%).Polyphenol-,phytosterol-,and saponin-rich extracts from Azufrasin and FJ Dalia were evaluated in 3T3 L1 cells.Both varieties up-regulated,Cpt1a and Acadm(fatty acidβ-oxidation),and Glut4,Irs1,and Pi3k(insulin signaling cascade)and down-regulated Pparg and Cebpa(adipogenesis)and Fasn and Acaca(lipogenesis).These activities were associated with their high content of soyasaponins A3,Af,and Be for adipogenesis and lipid metabolism,as well as eriodictyol,ellagic acid,hesperidin and(+)-catechin and(-)-epicatechin and their derivatives,andβ-campesterol hexoside for insulin signaling cascade.FJ Dalia and Azufrasin cooked beans could be consumed to ameliorate obesity and its metabolic complications.

关 键 词：3T3 L1 cells Common beans Phaseolus vulgaris L. DYSLIPIDEMIA Insulin resistance PHYTOCHEMICALS 

分 类 号：TS201.4[轻工技术与工程—食品科学]