Development of selenium nanoparticles stabilized by novel polysaccharides from Stauntonia brachyanthera pulp for anti-hepatoma cell proliferation  

作　　者：Ningxiang Yu Hui Chen Abel Wend-Soo Zongo Yuanchao Lu Xiaohua Nie Xianghe Meng 

机构地区：[1]College of Food Science and Technology,Zhejiang University of Technology,Hangzhou,310014,Zhejiang,China

出　　处：《Food Bioscience》2023年第3期2803-2811,共9页食品生物科学（英文）

基　　金：financial support provided by the National Natural Science Foundation of China(32272242,32001739,31972109,31772001);Zhejiang Province Key Research and Develop-ment Projects(2023C04001,2021C02013,2020C2018,2019C04022,2019C02069,LGN21C20005,LQ22C200018).

摘　　要：In this study,the novel polysaccharides extracted from Stauntonia Brachyanthera pulp were used as stabilizers for the preparation of selenium nanoparticles(SBPPs-SeNPs).The preparation process,structural characterization,stability,and anti-hepatoma cell activity of SBPPs-SeNPs were studied in detail.The results showed that the SBPPs-SeNPs were symmetrical spheres with an average diameter of about 30-40 nm under optimal process parameters.SBPPs interacted with SeNPs via hydroxyl groups on the surface of SBPPs to form C-O-Se bonds.SBPPs-SeNPs exhibited good stability during the 21-day storage period at 4℃,likely due to the interaction between SeNPs and the hydroxyl groups.Moreover,in vitro anti-tumor experiments demonstrated that SBPPs-SeNPs significantly inhibited the proliferation of HepG2 cells in a dose-dependent manner,and induced morphological changes,and cell cycle arrest in S phase.SBPPs-SeNPs also triggered apoptosis in HepG2 cells through the mitochondrial pathway.Our findings suggested that SBPPs-SeNPs have the potential to become novel anti-hepatoma agents.

关 键 词：Stauntonia brachyanthera pulp polysaccharides Selenium nanoparticles Structural characterization Stability Anti-hepatoma activity 

分 类 号：TB383[一般工业技术—材料科学与工程] R735.7[医药卫生—肿瘤]