In-vitro gastrointestinal digestion of functional cookies enriched with chestnut shells extract:Effects on phenolic composition,bioaccessibility,bioactivity,andα-amylase inhibition  

作　　者：Diana Pinto Manuela M.Moreira Jaroslava Svarc-Gajic Anna Vallverdú-Queralt Tanja Brezo-Borjan Cristina Delerue-Matos Francisca Rodrigues 

机构地区：[1]REQUIMTE/LAQV,ISEP,Polytechnic of Porto,Rua Dr.António Bernardino de Almeida,4249-015,Porto,Portugal [2]Faculty of Technology,University of Novi Sad,Bulevar cara Lazara 1,21000,Novi Sad,Serbia [3]Nutrition,Food Science and Gastronomy Department,School of Pharmacy and Food Science,University of Barcelona,Barcelona,Spain [4]Consorcio CIBER,M.P.Fisiopatología de la Obesidad y la Nutrición(CIBERObn),Instituto de Salud CarlosⅢ(ISCⅢ),Madrid,Spain

出　　处：《Food Bioscience》2023年第3期3087-3100,共14页食品生物科学（英文）

基　　金：financial support from national funds(UIDB/50006/2020);project PTDC/ASP-AGR/29277/2017-Castanea sativa shells as a new source of active ingredients for Functional Food and Cosmetic applications:a sustainable approach,and project 5537 DRI,Sérvia 2020/21 from Portuguese-Serbia Bilateral Cooperation-Devel-opment of functional foods incorporating a chestnut shells extract obtained by subcritical water,supported by national funds by FCT/MCTES;co-supported by Fundo Europeu de Desenvolvimento Regional(FEDER)throughout COMPETE 2020-Programa Operacional Competitividade e Internacionalização(POCI-01-0145-FEDER-029277);Diana Pinto is thankful for her Ph.D.grant(SFRH/BD/144534/2019)financed by FCT/MCTES and POPH-QREN;supported by funds from European Union(EU)and Fundo Social Europeu(FSE)through Pro-grama Operacional Regional Norte;Francisca Rodrigues(CEECIND/01886/2020);Manuela M.Moreira(CEECIND/02702/2017);financed by FCT/MCTES-CEEC Individual 2020Program Contract;the Spanish Ministerio de Ciencia,Innovación y Universidades for the Ramon y Cajal contract(RYC-2016-19355);Jaroslava Svarc-Gajic and Tanja Brezo-Borjan are grateful to the Science Fund of the Republic of Serbia(Grant No.7747845,In situ pollutants removal from waters by sustainable green nanotechnologies-CleanNanoCatalyze);Ministry of education,science and technological development of the Republic of Serbia(Grant No 451-03-68/2020-14/200134).

摘　　要：Chestnut(Castanea sativa)shells(CS)are an appealing source of antioxidants.In previous studies,the research team validated a nutraceutical extract from CS,recovered by an eco-friendly technology,by in-vitro and in-vivo assays,and developed functional cookies enriched with this extract.This study attempts,for the first time,to investigate the impact of the in-vitro gastrointestinal digestion in the phenolic composition,bioaccessibility,antioxidant/antiradical properties,andα-amylase inhibition of CS extract-enriched cookies.The outcomes revealed higher polyphenols concentrations retained after intestinal digestion,endorsing its better antioxidant,antiradical,and hypoglycemic properties.The phenolics recovery enhanced in the following order:oral<gastric<intestinal phases,achieving 93.50%of maximum bioaccessibility and unveiling a protective effect of the cookie matrix and slow phenolics release during digestion.Regardless the identical composition in phenolic acids,changes in their concentrations were attested between digested and undigested cookies.Multivariate analysis predicted the outstanding contribution of polyphenols to the bioactivity of cookies.This study high-lighted the valorization of CS as nutraceutical ingredient for functional cookies,proving its efficacy after in-vitro digestion.

关 键 词：Castanea sativa ANTIOXIDANTS Functional food In-vitro simulated digestion Pro-healthy benefits 

分 类 号：TS201.2[轻工技术与工程—食品科学]