Genome analysis of SARS-CoV-2 haplotypes:separation and parallel evolution of the major haplotypes occurred considerably earlier than their emergence in China  

作　　者：Siqin Guan Xiaowen Hu Guohui Yi Lei Yao Jiaming Zhang 

机构地区：[1]Key Laboratory of Microbiology of Hainan,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou,Hainan 571101,China [2]College of Animal Sciences,Huazhong Agricultural University,Wuhan,Hubei Province 430070,China [3]Institute of South Subtropical Crops,Chinese Academy of Tropical Agricultural Sciences,Zhanjiang 524013,China [4]Public Research Laboratory,Hainan Medical University,Haikou 571199,China [5]Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics,Department of Laboratory Medicine,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital,University of Electronic Science and Technology,Chengdu 610054,China

出　　处：《Science in One Health》2023年第1期149-155,共7页全健康科学（英文）

基　　金：supported by grants from the National Key R&D Program of China and the Central Public-interest Scientific Institution Basal Research Fund to J.Z.(1630052020022);by the Project of Science and Technology Department of Sichuan Provincial of China to L.Y.(2019JDJQ0035).

摘　　要：More than 3 years have passed since the outbreak of COVID-19 and yet, the origin of the causal virus SARS-CoV-2 remains unknown. We examined the evolutionary trajectory of SARS-CoV-2 by analyzing non-redundant genome sets classified based on six closely linked mutations. The results indicated that SARS-CoV-2 emerged in February 2019 or earlier and evolved into three main haplotypes (GL, DS, and DL) before May 2019, which then continued to evolve in parallel. The dominant haplotype GL had spread worldwide in the summer (May to July) of 2019 and then evolved into virulent strains in December 2019 that triggered the global pandemic, whereas haplotypes DL and DS arrived in China in October 2019 and caused the epidemic in China in December 2019. Therefore, haplotype GL neither originated in China nor from the viral strains that caused the epidemic in China. Accordingly, considering data solely from China would be inadequate to reveal the mysterious origin of SARS-CoV-2, emphasizing the necessity of global cooperation.

关 键 词：SARS-CoV-2 HAPLOTYPE Genome classification MRCA Phylogenetic analysis 

分 类 号：F42[经济管理—产业经济]