胞磷胆碱注射液联合微创穿刺引流术治疗对中等量高血压性基底节区脑出血患者脑水肿、血清AQP4的影响  

Effect of Citicoline Injection Combined with Minimally Invasive Puncture Drainage on Brain Edema and Serum AQP4 in Patients with Moderate Hypertensive Basal Ganglia Hemorrhage

作　　者：郭晓泉 GUO Xiaoquan(Department of Neurosurgery,Suichuan County People's Hospital,Suichuan 343900,Jiangxi,China)

机构地区：[1]遂川县人民医院神经外科,江西遂川343900

出　　处：《医学信息》2024年第24期48-51,共4页Journal of Medical Information

摘　　要：目的研究胞磷胆碱注射液联合微创穿刺引流术治疗对中等量高血压性基底节区脑出血患者脑水肿、血清AQP4的影响。方法选取2020年6月-2023年6月在我院诊治的80例中等量高血压性基底节区脑出血患者为研究对象,采用随机数字表法分为对照组和观察组,各组40例。对照组采用胞磷胆碱注射液治疗,观察组在对照组基础上给予微创穿刺引流术,比较两组临床疗效、神经功能缺损(NIHSS)评分、脑水肿体积、血清AQP4水平、日常生活活动能力(ADL)分级情况。结果观察组治疗总有效率为95.00%,高于对照组的82.50%(P<0.05);两组治疗后NIHSS评分均低于治疗前,且观察组低于对照组(P<0.05);两组治疗后脑水肿体积均小于治疗前,血清AQP4水平低于治疗前,且观察组脑水肿体积、血清AQP4水平均小于对照组(P<0.05);观察组ADL分级Ⅰ级、Ⅱ级占比均高于对照组,Ⅲ级、Ⅳ级占比均低于对照组(P<0.05)。结论中等量高血压性基底节区脑出血患者采用胞磷胆碱注射液联合微创穿刺引流术治疗可提高治疗总有效率,促进神经功能恢复,减小脑水肿体积,降低血清AQP4水平,改善患者日常生活能力水平,具有较理想的临床治疗效果。Objective To study the effect of citicoline injection combined with minimally invasive puncture and drainage on cerebral edema and serum AQP4 in patients with moderate hypertensive basal ganglia hemorrhage.Methods A total of 80 patients with moderate hypertensive basal ganglia hemorrhage who were treated in our hospital from June 2020 to June 2023 were selected as the research objects.They were divided into control group and observation group by random number table method,with 40 patients in each group.The control group was treated with citicoline injection,and the observation group was treated with minimally invasive puncture and drainage on the basis of the control group.The clinical efficacy,neurological deficit(NIHSS)score,brain edema volume,serum AQP4 level and activity of daily living(ADL)classification were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than 82.50%in the control group(P<0.05).The NIHSS score of the two groups after treatment was lower than that before treatment,and that of the observation group was lower than that of the control group(P<0.05).After treatment,the volume of brain edema in the two groups was smaller than that before treatment,the level of serum AQP4 was lower than that before treatment,and the volume of brain edema and the level of serum AQP4 in the observation group were smaller than those in the control group(P<0.05).The proportion of ADL gradeⅠandⅡin the observation group was higher than that in the control group,and the proportion of gradeⅢandⅣwas lower than that in the control group(P<0.05).Conclusion The application of citicoline injection combined with minimally invasive puncture and drainage in patients with moderate hypertensive basal ganglia intracerebral hemorrhage can improve the total effective rate of treatment,promote the recovery of neurological function,reduce the volume of cerebral edema,reduce the level of serum AQP4,and improve the level of daily living ability of p

关 键 词：胞磷胆碱注射液 微创穿刺引流术 高血压性 基底节区脑出血 脑水肿 

分 类 号：R743.34[医药卫生—神经病学与精神病学]