生长抑素联合大剂量奥美拉唑对急性上消化道大出血的临床疗效及对血红蛋白水平的影响  

Clinical Effect of Somatostatin Combined with High-dose Omeprazole on Acute Upper Gastrointestinal Hemorrhage and its Effect on Hemoglobin Level

作　　者：李兰富 LI Lanfu(Department of Gastroenterology,Yanbian County People's Hospital,Yanbian 617199,Sichuan,China)

机构地区：[1]盐边县人民医院消化科,四川盐边617199

出　　处：《医学信息》2024年第24期77-80,共4页Journal of Medical Information

摘　　要：目的分析生长抑素联合大剂量奥美拉唑对急性上消化道大出血的临床疗效及对患者血红蛋白水平的影响。方法选取我院2022年1月-2023年7月收治的60例急性上消化道大出血患者作为研究对象,按照随机数字表法将其分为对照组和研究组,每组各30例。对照组使用大剂量奥美拉唑治疗,研究组在对照组的基础上给予注射用生长抑素治疗。比较两组临床治疗效果、血红蛋白水平及凝血功能指标(凝血酶原时间、活化部分凝血活酶时间、血小板计数、纤维蛋白原)。结果研究组治疗总有效率高于对照组(P<0.05);治疗后,研究组血红蛋白水平高于对照组(P<0.05);研究组凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原水平均低于对照组,而血小板计数高于对照组(P<0.05)。结论生长抑素联合大剂量奥美拉唑治疗急性上消化道大出血的临床疗效确切,能够提高患者血红蛋白水平,改善患者凝血功能,值得临床应用。Objective To analyze the clinical effect of somatostatin combined with high-dose omeprazole on acute upper gastrointestinal hemorrhage and its effect on hemoglobin level.Methods A total of 60 patients with acute upper gastrointestinal hemorrhage admitted to our hospital from January 2022 to July 2023 were selected as the research objects.They were divided into control group and study group according to the random number table method,with 30 patients in each group.The control group was treated with high-dose omeprazole,and the study group was treated with somatostatin for injection on the basis of the control group.The clinical efficacy,hemoglobin level and coagulation function indexes(prothrombin time,activated partial thromboplastin time,platelet count,fibrinogen)were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).After treatment,the hemoglobin level of the study group was higher than that of the control group(P<0.05).The prothrombin time,activated partial thromboplastin time and fibrinogen level in the study group were lower than those in the control group,while the platelet count was higher than that in the control group(P<0.05).Conclusion Somatostatin combined with high-dose omeprazole is effective in the treatment of acute upper gastrointestinal hemorrhage,which can improve the hemoglobin level and improve the coagulation function of patients.It is worthy of clinical application.

关 键 词：生长抑素 奥美拉唑 急性上消化道大出血 血红蛋白 

分 类 号：R573.2[医药卫生—消化系统]