血液检验红细胞参数在地中海贫血与缺铁性贫血中的鉴别诊断价值  

Value of Red Blood Cell Parameters in Differential Diagnosis of Thalassemia and Iron Deficiency Anemia

作　　者：黄艳平[1] 毕卫红[2] HUANG Yanping;BI Weihong(Department of Transfusion Blood,Shanggao County People'sHospital,Shanggao 336400,Jiangxi,China;Department of Physical Examination,Shanggao County People'sHospital,Shanggao 336400,Jiangxi,China)

机构地区：[1]上高县人民医院输血科,江西上高336400 [2]上高县人民医院体检科,江西上高336400

出　　处：《医学信息》2024年第23期86-89,共4页Journal of Medical Information

摘　　要：目的分析血液检验红细胞参数在地中海贫血与缺铁性贫血中的鉴别诊断价值。方法选取2021年1月-2023年9月我院诊治的地中海贫血(n=38)与缺铁性贫血(n=38)患者为研究对象,并选取同期38例在我院体检健康者为对照组,各组均进行血常规检测,比较三组平均红细胞血红蛋白量(MCH)、血红蛋白(Hb)、红细胞计数(RBC)、红细胞平均分布宽度(RDW)、红细胞平均体积(MCV)、血清铁(SI)、血清铁蛋白(SF),以及不同类型地中海贫血与缺铁性贫血患者血液检验红细胞参数,并分析红细胞参数对地中海贫血与缺铁性贫血的鉴别诊断效能(灵敏度、特异度、准确率、阳性预测值、阴性预测值)。结果地中海贫血组、缺铁性贫血组Hb、MCH、MCV均低于对照组,RDW高于对照组(P<0.05),地中海贫血组Hb、MCH、RBC均高于缺铁性贫血组,而地中海贫血组MCV、RDW均低于缺铁性贫血组(P<0.05);缺铁性贫血组SF、SI均低于对照组,地中海贫血组SF高于对照组,且缺铁性贫血组SF低于地中海贫血组(P<0.05);缺铁性贫血组RDW、RBC、MCV、MCH均高于α-地中海贫血和β-地中海贫血患者,Hb低于α-地中海贫血和β-地中海贫血患者(P<0.05);α-地中海贫血患者RBC、Hb均低于β-地中海贫血患者,MCV高于β-地中海贫血患者(P<0.05),但RDW、MCH与β-地中海贫血患者比较,差异无统计学意义(P>0.05);血液检验红细胞参数诊断地中海贫血、缺铁性贫血灵敏度、特异度、准确率、阳性预测值、阴性预测值比较,差异无统计学意义(P>0.05)。结论地中海贫血与缺铁性贫血患者血液检验红细胞参数存在差异,且不同类型地中海贫血患者部分指标存在差异,对地中海贫血与缺铁性贫血鉴别诊断均具有较高的诊断效能,值得临床予以重视。Objective To analyze the value of blood test red blood cell parameters in the differential diagnosis of thalassemia and iron deficiency anemia.Methods Patients with thalassemia(n=38)and iron deficiency anemia(n=38)diagnosed and treated in our hospital from January 2021 to September 2023 were selected as the research objects,and 38 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.Blood routine tests were performed in each group.The mean corpuscular hemoglobin(MCH),hemoglobin(Hb),red blood cell count(RBC),mean red blood cell distribution width(RDW),mean corpuscular volume(MCV),serum iron(SI)and serum ferritin(SF)were compared among the three groups.The red blood cell parameters of patients with different types of thalassemia and iron deficiency anemia were tested,and the differential diagnostic efficacy of red blood cell parameters for thalassemia and iron deficiency anemia(sensitivity,specificity,accuracy,positive predictive value,negative predictive value)was analyzed.Results Hb,MCH and MCV in thalassemia group and iron deficiency anemia group were lower than those in control group,and RDW was higher than that in control group(P<0.05).Hb,MCH and RBC in thalassemia group were higher than those in iron deficiency anemia group,while MCV and RDW in thalassemia group were lower than those in iron deficiency anemia group(P<0.05).SF and SI in iron deficiency anemia group were lower than those in control group,SF in thalassemia group was higher than that in control group,and SF in iron deficiency anemia group was lower than that in thalassemia group(P<0.05).RDW,RBC,MCV and MCH in iron deficiency anemia group were higher than those inα-thalassemia andβ-thalassemia patients,and Hb was lower than that inα-thalassemia andβ-thalassemia patients(P<0.05).RBC and Hb in patients withα-thalassemia were lower than those in patients withβ-thalassemia,MCV was higher than that in patients withβ-thalassemia(P<0.05),but RDW and MCH were not significantly d

关 键 词：血液检验 红细胞参数 地中海贫血 缺铁性贫血 鉴别诊断 

分 类 号：R446.11[医药卫生—诊断学]