超敏C反应蛋白和D-二聚体及同型半胱氨酸水平在急性脑梗死患者中的表达意义及其与预后的相关性  

Significance of hs-CRP,D-D and Hcy levels in patients with acute cerebral infarction and their correlation with prognosis

作　　者：韦奕铭 李春妍 邓世旺 WEI Yiming;LI Chunyan;DENG Shiwang(Xinyi Traditional Chinese Medicine Hospital,Xinyi 525300,China)

机构地区：[1]信宜市中医院,广东信宜525300

出　　处：《临床医药实践》2025年第1期19-22,共4页Proceeding of Clinical Medicine

摘　　要：目的:探讨超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)、同型半胱氨酸(Hcy)在急性脑梗死(ACI)患者中的表达意义及其与预后的相关性。方法:选取2021年1月—2023年12月体检的健康人群150例作为对照组,选取同期收治的ACI患者150例作为观察组。按照病情严重程度将150例ACI患者分为重度组(32例)、中度组(64例)、轻度组(54例);依据梗死面积将其分为小、中、大梗死组,分别为51例、70例、29例,同时根据预后情况将其分为预后良好组(96例)和不良组(54例)。比较对照组和观察组不同病情严重程度、不同梗死面积、不同预后ACI患者hs-CRP,D-D,Hcy水平;受试者工作曲线(ROC)分析hs-CRP,D-D,Hcy水平对ACI患者预后的临床价值。结果:观察组hs-CRP,D-D,Hcy水平均高于对照组,差异有统计学意义(P<0.05);重度组、大梗死组、预后不良组hs-CRP,Hcy,D-D水平分别高于中、轻度组和中、小梗死组及预后良好组(P<0.05);ROC曲线分析示,hs-CRP,D-D,Hcy水平联合检测的曲线下面积(AUC)值最高,为0.940,且灵敏度、特异度分别为85.19%和92.71%。结论:ACI患者的hs-CRP,D-D,Hcy水平较高,且ACI病情越严重,hs-CRP,D-D,Hcy水平越高。hs-CRP,D-D,Hcy联合检测评估ACI患者预后具有较高的诊断效能。Objective:To investigate the significance of the expression of ultrasensitive C-reactive protein(hs-CRP),D-dimer(D-D)and homocysteine(Hcy)in patients with acute cerebral infarction(ACI)and their correlation with prognosis.Methods:All 150 cases each of healthy people and ACI patients admitted to hospital for physical examination from January 2021 to December 2023 were selected as the control group and observation group.According to the severity of the disease,the 150 ACI patients were classified into 32,64,and 54 cases in the severe,moderate,and mild groups,and into 51,70,and 29 cases in the small,medium,and large infarct groups according to the infarct area,as well as into 96 and 54 cases in the good and bad prognosis groups according to the prognosis.The hs-CRP,D-D,and Hcy levels of ACI patients in the observation group,control group,different disease severity,different infarct size,and different prognosis were compared,and ROC analyses were performed to assess the clinical value of hs-CRP,D-D,and Hcy levels in evaluating the prognosis of ACI patients.Results:Compared with the control group,hs-CRP,D-D,and Hcy levels were higher in the observation group(P<0.05).The level of hs-CRP,Hcy,and D-D were higher in the severe group,large infarction group,and poor prognosis group than those in the moderate and mild group,and the medium and small infarction group and poor prognosis group,respectively(P<0.05).ROC curve analysis showed that the AUC value of hs-CRP,D-D and Hcy levels was the highest,which was 0.940,and the sensitivity and specificity were 85.19%and 92.71%respectively.Conclusion:Compared with the normal population,ACI patients had higher hs-CRP,D-D and Hcy levels,and the more severe the ACI disease,the higher the hs-CRP,D-D and Hcy levels.The combined detection of hs-CRP,D-D,Hcy has high diagnostic efficiency in evaluating the prognosis of ACI patients.

关 键 词：急性脑梗死 超敏C反应蛋白 D-二聚体 同型半胱氨酸 临床价值 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学]