不同中药铁剂配方产品对大鼠缺铁性贫血功能的影响  

Effect of Different Traditional Chinese Medicine Iron Formulations on Iron Deficiency Anemia in Rats

作　　者：孙欣欣[1] 李怡芳[2] 陈庆淑 张卫华 王敏[3] SUN Xinxin;LI Yifang;CHEN Qingshu;ZHANG Weihua;WANG Min(Jiujiang Maternal and Child Health Hospital,Jiujiang Jiangxi 332001,China;School of Pharmacy/Institute of Traditional Chinese Medicine and Natural Medicine,Ji'nan University,Guangzhou Guangdong 510632,China;Hainan Provincial People's Hospital,Haikou Hainan 570311,China;Health Food Branch of National Modern Engineering Technology Research Center for Traditional Chinese Medicine,Guangzhou Guangdong 510403,China)

机构地区：[1]九江市妇幼保健院,江西九江332001 [2]暨南大学药学院/暨南大学中药及天然药物研究所,广东广州510632 [3]海南省人民医院,海南海口570311 [4]国家中药现代化工程技术研究中心保健食品分中心,广东广州510403

出　　处：《中医药导报》2024年第12期28-32,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(82060749)。

摘　　要：目的:研究不同中药铁剂配方产品对大鼠缺铁性贫血功能的影响。方法:设模型对照组和实验组,实验组为6组。其中4组(配方二至配方五组)应用4种不同中药配方联合乳酸亚铁,1组(配方六组)仅使用中药配方,1组(配方一组)仅使用乳酸亚铁,并且各个实验组使用不同的药物剂量。连续经口灌胃给予大鼠不同实验组的治疗方案,30 d后进行检测,将所测各项指标结果分别与模型对照组比较。结果:所有配方各剂量组大鼠体质量与模型对照组比较,差异均无统计学意义(P>0.05)。配方一至五各剂量组及配方六高剂量组均能提高大鼠的血红蛋白和红细胞压积两项指标(P<0.01),配方六低剂量组可提高大鼠的血红蛋白(P<0.01),对于红细胞压积有升高的趋势,但差异无统计学意义(P>0.05);所有配方各剂量组对大鼠的红细胞内游离原卟啉无明显提升(P>0.05)。结论:中药铁剂配方产品对大鼠缺铁性贫血有明显的改善作用,为缺铁性贫血的治疗提供更多的选择。Objective:To investigate the effects of different traditional Chinese medicine iron formulations on iron deficiency anemia in rats.Methods:A model control group and six experimental groups were set up.And four experimental groups received four different traditional Chinese medicine formulations combined with ferrous lactate;A experimental group received only the traditional Chinese medicine formulation,and a experimental group received only ferrous lactate.Different doses of the drugs were administered orally to the rats in the experimental groups for 30 days.Various indicators measured were compared with those of the model control group.Results:Compared to the model control group,no significant changes were observed in body weight in any of the experimental groups(P>0.05).All doses of formulations of the first to fifth experimental groups and the high dose of formulation of sixth group resulted in increased levels of hemoglobin and hematocrit in the rats(P<0.01).The low dose of formulation sixth increased hemoglobin levels(P<0.01) and showed a tendency to increase hematocrit,although the difference was not statistically significant(P>0.05).None of the doses showed a significant effect on free protoporphyrin levels in rat red blood cells(P>0.05).Conclusion:Traditional Chinese medicine iron formulations can provide obvious improvement effect on iron deficiency anemia in rats,providing more options for the treatment of this condition.

关 键 词：缺铁性贫血 中药铁剂配方 乳酸亚铁 四物汤 大鼠 

分 类 号：R285.5[医药卫生—中药学]