胰腺疾病体外细胞模型研究进展  

A review on cell-based models of human pancreatic diseases in vitro

作　　者：朱卫丰 彭立军 刘婧[2] 彭淑红 ZHU Wei-feng;PENG Li-jun;LIU Jing;PENG Shu-hong(Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Chinese Medicine;School of Pharmacy,Jiangxi University of Chinese Medicine;Research Center for Differentiation and Development of Traditional Chinese Medicine Basic Theory,Jiangxi University of Chinese Medicine;Jiangxi Provincial Key Laboratory of Chinese Medicine Etiopathogenisis,Nanchang 330004,China)

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室 [2]江西中医药大学药学院 [3]江西中医药大学中医基础理论分化发展研究中心 [4]江西中医药大学江西省中医病因生物学重点实验室,江西南昌33000

出　　处：《中国药理学通报》2025年第1期23-29,共7页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 82160830);江西中医药大学创新创业训练计划(No X202310412126)。

摘　　要：不健康的饮食、吸烟、饮酒会引起多种胰腺疾病,包括胰腺炎、糖尿病和胰腺癌等,严重威胁人体健康。构建体外细胞模型在研究胰腺疾病的病因病机及其药物的开发及筛选中具有重要意义。目前,国内外学者已开发出多种体外胰腺疾病模型。该文概括了常见胰腺疾病的体外细胞模型,并从模型细胞的特性、培养方式、造模方式、评价指标等方面进行综述,以期为胰腺疾病相关研究人员提供参考。Unhealthy diet,smoking and drinking can cause a variety of pancreatic diseases,including pancreatitis,diabetes and pancreatic cancer,which seriously threaten human health.The construction of cell models in vitro is of great significance in the study of the etiology and pathogenesis of pancreatic diseases and the development and screening of medicines.At present,domestic and foreign scholars have developed a variety of in vitro pancreatic disease models.In this paper,we summarize the cell models of common pancreatic diseases in vitro,and review the characteristics,culture methods,modeling methods,and evaluation indexes of the model cells,so as to provide references for researchers related to pancreatic diseases.

关 键 词：胰腺疾病 细胞模型 细胞特性 培养方式 造模方法 评价指标 

分 类 号：R576[医药卫生—消化系统]