宫颈癌组织中FOLR1、MSLN表达及其与临床病理特征的关系  

Expressions of FOLR1 and MSLN in cervical cancer tissues and their relationship with clinicopathological characteristics

作　　者：刘佳 姜丽[2] 李佳维 李秀福 LIU Jia;JIANG Li;LI Jiawei;LI Xiufu(Medical Insurance Administration,the First Hospital of Qinhuandao,Qinhuangdao,Hebei,China,066000;Gynaecology Department of Medical Insurance Administration,the First Hospital of Qinhuandao,Qinhuangdao,Hebei,China,066000)

机构地区：[1]秦皇岛市第一医院医疗保险管理处,河北秦皇岛066000 [2]秦皇岛市第一医院医疗保险管理处妇科,河北秦皇岛066000

出　　处：《分子诊断与治疗杂志》2024年第12期2320-2323,2328,共5页Journal of Molecular Diagnostics and Therapy

基　　金：秦皇岛市重点研发计划科技支撑项目(202004A060)。

摘　　要：目的探讨宫颈癌组织中叶酸受体1(FOLR1)、间皮素(MSLN)表达及其与临床病理特征的关系。方法选取2022年1月至2023年1月秦皇岛市第一医院收治的80例宫颈癌患者作为研究对象,采用免疫组化方法检测宫颈癌组织及其癌旁组织中FOLR1、MSLN的表达情况,并分析宫颈癌组织中FOLR1、MSLN表达与临床病理特征的关系;根据患者术后1年复发情况分为复发组和非复发组,比较两组临床资料,采用多因素回归分析宫颈癌患者术后复发的影响因素。结果宫颈癌组织中FOLR1、MSLN阳性表达高于癌旁组织,差异有统计学意义(P<0.05);病理类型为鳞癌、中低分化、FIGO分期Ⅱa期、有淋巴结转移的宫颈癌患者FOLR1和MSLN表达高于病理类型为腺癌、高分化、FIGO分期Ⅰa+Ⅰb期、无淋巴结转移的患者,差异有统计学意义(P<0.05);随访1年,22例患者发生复发。复发组和非复发组病理类型、分化程度、FIGO分期、淋巴结转移、FOLR1表达、MSLN表达比较差异具有统计学意义(P<0.05);采用二元Logistic分析,中+低分化、淋巴结转移、FOLR1表达阳性、MSLN表达阳性均为影响宫颈癌患者术后复发的独立危险因素(P<0.05)。结论宫颈癌组织中FOLR1、MSLN阳性表达升高,且与患者临床病理特征密切相关,二指标可为预测术后复发提供参考。Objective To explore the expressions of folate receptor 1(FOLR1)and mesothelin(MSLN)in cervical cancer tissues and their relationship with clinicopathological characteristics.Methods A total of 80 patients with cervical cancer were admitted to the First Hospital of Qinhuandao and enrolled as re⁃search subjects between January 2022 and January 2023.The expressions of FOLR1 and MSLN in cervical can⁃cer tissues and para⁃carcinoma tissues were detected using immunohistochemistry,and the relationship be⁃tween FOLR1 and MSLN in cervical cancer tissues and clinicopathological characteristics was analyzed.Based on the presence or absence of recurrence at 1 year after surgery,patients were divided into a recurrence group and a non⁃recurrence group.The clinical data in the two groups were compared.The influencing factors of post⁃operative recurrence in patients with cervical cancer were analyzed using multivariate regression analysis.Results The positive expressions of FOLR1 and MSLN in cervical cancer tissues were higher than those in para⁃carcinoma tissues(P<0.05).The expressions of FOLR1 and MSLN in cervical cancer patients with patho⁃logical type of squamous cell carcinoma,moderate to low differentiation,FIGO stage IIa,and lymph node metastasis were higher than those in patients with pathological type of adenocarcinoma,highly differentiated,FIGO stageⅠa+Ⅰb,and no lymph node metastasis(P<0.05).After 1 year of follow⁃up,there were 21 cases with recurrence.There were significant differences in pathological types,differentiation degree,FIGO stag⁃ing,lymph node metastasis,expressions of FOLR1 and MSLN between the recurrence group and non⁃recur⁃rence group(P<0.05).Binary logistic analysis revealed that high differentiation,lymph node metastasis,and positive expressions of FOLR1 and MSLN were independent risk factors for postoperative recurrence in pa⁃tients with cervical cancer(P<0.05).Conclusion The levels of FOLR1 and MSLN expression in cervical cancer tissues are elevated.These two indicators

关 键 词：宫颈癌 叶酸受体1 间皮素 临床病理特征 

分 类 号：R737.33[医药卫生—肿瘤]