急性胰腺炎患者外周血FGF⁃21、NLRP3炎症小体表达与预后的关系  

Relationship between the expression of FGF⁃21 and NLRP3 inflammasome in peripheral blood and prognosis in patients with acute pancreatitis

作　　者：李凌青 陈玲 陈小沛 孙彦婷[3] 俞军[3] LI Lingqing;CHEN Ling;CHEN Xiaopei;SUN Yanting;YU Jun(Department of Gastroenterology,Nanjing Pukou People's Hospital,Nanjing,Jiangsu,China,211800;Emergency Department,Nanjing Pukou People's Hospital,Nanjing,Jiangsu,China,211800;Depart-ment of Infectious Disease,Jiangsu Cancer Hospital,Nanjing,Jiangsu,China,210009)

机构地区：[1]南京市浦口人民医院消化内科,江苏南京211800 [2]南京市浦口人民医院急诊科,江苏南京211800 [3]江苏省肿瘤医院感染科,江苏南京210009

出　　处：《分子诊断与治疗杂志》2024年第12期2355-2359,共5页Journal of Molecular Diagnostics and Therapy

基　　金：江苏省卫生健康委科研项目(ZD2021012)。

摘　　要：目的分析急性胰腺炎(AP)患者外周血成纤维细胞生长因子21(FGF⁃21)、NLRP3炎症小体表达水平与预后的关系。方法选择2022年2月至2024年2月在南京市浦口人民医院就诊的120例AP患者,根据AP疾病等级分为轻症AP 62例、中重症AP 31例、重症AP 27例,按照入院28 d后预后情况分为死亡组25例和存活组95例。入院后检测患者外周血FGF⁃21、NLRP3炎症小体表达水平,收集患者临床相关资料。比较两组外周血FGF⁃21、NLRP3炎症小体表达水平和临床相关资料差异,采用多因素logistic回归分析AP患者预后影响因素。结果不同疾病严重程度的FGF⁃21水平、NLRP3炎症小体表达水平呈现:重症AP>中重症AP>轻症AP,差异均有统计学意义(P<0.05)。死亡组外周血FGF⁃21、NLRP3表达水平高于存活组,差异有统计学意义(P<0.05)。死亡组合并糖尿病比例、急性生理与慢性健康评分Ⅱ(APACHEⅡ)、血肌酐(Scr)、C反应蛋白(CRP)、降钙素原(PCT)水平高于存活组,差异均有统计学意义(P<0.05)。经logistic逐步回归分析得出FGF⁃21、NLRP3炎症小体是AP患者入院28 d后死亡的独立危险因素(P<0.05)。结论AP患者中外周血FGF⁃21、NLRP3炎症小体表达水平异常升高,二者在评估AP患者病情进展及预后方面具有一定辅助作用。Objective To analyze the relationship between the expression levels of FGF-21 and NLRP3 inflammasome in peripheral blood and prognosis in patients with AP.Methods A total of 120 patients with AP were admitted to Nanjing Pukou People's Hospital from February 2022 to February 2024.They were divided into three groups:mild AP(62 cases),moderate-severe AP(31 cases)and severe AP(27 cases)based on their disease severity.Additionally,patients were categorized into a death group(25 cases)and a survival group(95 cases)base don their prognosis on day 28 after admission.After admission,the levels of FGF-21 and NLRP3 inflammasome in peripheral blood were measured.Relevant clinical data were collected.The expression levels of FGF-21 and NLRP3 inflammasome in peripheral blood and relevant data were compared between different groups.Prognostic factors for patients with AP were identified through multivariate logistic regression analysis.Results The expression levels of FGF-21 and NLRP3 inflammasome in the peripheral blood of patients with severe AP,moderate-severe AP,and mild AP decreased in order(P<0.05).The expression levels of FGF-21 and NLRP3 inflammasome in the peripheral blood of the death group were higher than those in the survival group(P<0.05).The proportion of patients with diabetes,APACHEⅡscores,serum Scr,CRP,and PCT levels in the death group were higher than those in the survival group(P<0.05).Logistic regression analysis showed that FGF-21 and NLRP3 inflammasome were independent risk factors for death in patients with AP 28 days after admission(P<0.05).Conclusion The levels of FGF-21 and NLRP3 inflammasome expression in the peripheral blood of patients with AP are abnormally elevated.Both markers can be used to assess disease progression and prognosis in patients with AP.

关 键 词：急性胰腺炎 外周血 成纤维细胞生长因子21 NLRP3炎症小体 

分 类 号：R576[医药卫生—消化系统]