地西他滨联合半剂量HAG在老年急性髓细胞白血病中的应用  

Application of decitabine combined with half⁃dose HAG in elderly patients with acute myeloid leukemia

作　　者：常礼 付彪 易俊 CHANG Li;FU Biao;YI Jun(Department General Medicine,Jinzhai County People's Hospital,Lu’an,Anhui,China,237300;Department Hematology and Oncology,Jinzhai County People's Hospital,Lu’an,Anhui,China,237300)

机构地区：[1]金寨县人民医院全科医学科,安徽六安237300 [2]金寨县人民医院血液肿瘤科,安徽六安237300

出　　处：《分子诊断与治疗杂志》2024年第12期2373-2376,2385,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生健康科研项目(AHWJ2022c002)。

摘　　要：目的探讨地西他滨联合半剂量HAG化疗方案对老年急性髓细胞白血病患者血清碱性成纤维细胞生长因子(bFGF)、环氧化酶⁃2(COX⁃2)、血管内皮生长因子(VEGF)水平和免疫功能的影响。方法选取2021年1月至2024年1月金寨县人民医院收治的老年急性髓细胞白血病患者80例,采用随机数字表法分为A组40例(予以HAG化疗方案)与B组40例(予以地西他滨结合半剂量HAG化疗方案),两组均治疗7 d。比较两组治疗7 d后的疗效,比较两组治疗前和治疗7 d后血清COX⁃2、bFGF、VEGF水平和全血CD4^(+)、CD3^(+)、CD8^(+)、白细胞(WBC)、血小板(PLT)和红细胞(RBC)水平、CD4^(+)/CD8^(+)。结果治疗7 d后,B组总有效率高于A组,差异有统计学意义(P<0.05)。与治疗前比较,治疗7 d后两组血清bFGF、VEGF、COX⁃2水平均降低,且B组低于A组,差异有统计学意义(P<0.05)。与治疗前比较,治疗7 d后两组全血CD3^(+)、CD4^(+)水平和CD4^(+)/CD8^(+)均升高,且B组高于A组,差异有统计学意义(P<0.05),治疗前后和两组组间比较,CD8^(+)水平变化均无统计学意义(P>0.05)。与治疗前比较,治疗7 d后两组全血WBC水平均降低,且B组低于A组,差异有统计学意义(P<0.05),两组全血PLT、RBC水平则均升高,且B组高于A组,差异有统计学意义(P<0.05)。结论采用地西他滨联合半剂量HAG化疗方案治疗能显著降低老年急性髓细胞白血病患者血清COX⁃2、bFGF、VEGF水平,有效改善患者免疫功能和血常规指标,具有良好的治疗效果。Objective To explore the effects of the combination of decitabine and half dose HAG chemotherapy regimen on serum levels of basic fibroblast growth factor(bFGF),cyclooxygenase⁃2(COX⁃2),vascular endothelial growth factor(VEGF),and immune function in elderly patients with acute myeloid leukemia.Methods Eighty elderly patients with acute myeloid leukemia were admitted to Jinzhai People's Hospital from January 2021 to January 2024.They were randomly divided into two groups:group A(40 cases received HAG chemotherapy)and group B(40 cases received decitabine combined with half⁃dose HAG che⁃motherapy).Both groups underwent treatment for 7 days,and the therapeutic effects of the two groups were compared after this period.The levels of serum COX⁃2,bFGF and VEGF,and the levels of CD4^(+),CD3^(+),CD8^(+),white blood cells(WBC),platelets(PLT)and red blood cells(RBC)and CD4^(+)/CD8^(+)in whole blood were compared before and after 7 days of treatment.Results After 7 days of treatment,the total effective rate in group B was higher than that in group A,and the difference was statistically significant(P<0.05).Compared to before treatment,the serum levels of bFGF,VEGF,and COX⁃2 in both groups decreased after 7 days of treatment,with levels in group B were lower than those in group A(P<0.05).Furthermore,the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in whole blood increased after 7 days of treatment in both groups,with the in⁃crease in group B being higher than in group A(P<0.05).There was no significant difference in the level of CD8^(+)between the two groups before and after treatment(P>0.05).Additionally,after 7 days of treatment,the level of whole blood WBC in both groups decreased,with group B showing a lower level than group A(P<0.05).Conversely,the levels of whole blood PLT and RBC in both groups increased,with group B having higher levels than group A(P<0.05).Conclusion The combination of decitabine and half⁃dose HAG chemotherapy can significantly reduce the serum levels of COX⁃2,bFGF,and VEGF in elderly

关 键 词：急性髓细胞白血病 地西他滨 HAG化疗 血管内皮生长因子 碱性成纤维细胞生长因子 环氧化酶⁃2 

分 类 号：R733.71[医药卫生—肿瘤]