抗阻运动训练对糖尿病患者腹腔镜手术后认知功能的影响  

Effects of resistance exercise training on cognitive function of diabetes patients after laparoscopic surgery

作　　者：朱春妹 柏杨 王九荣 ZHU Chunmei;BAI Yang;WANG Jiurong(Suzhou Ninth People's Hospital,Wujiang District,Suzhou,Jiangsu,China,215200)

机构地区：[1]苏州市第九人民医院,江苏苏州215200

出　　处：《分子诊断与治疗杂志》2024年第12期2386-2389,共4页Journal of Molecular Diagnostics and Therapy

基　　金：苏州市第九人民医院院级科研院(201916)。

摘　　要：目的研究抗阻运动训练对糖尿病患者腹腔镜手术后认知功能及血清髓系细胞触发受体2(TREM2)、核因子κB(NF-κB)、信号传导和转录激活蛋白3(STAT3)的影响。方法选择2022年4月至2023年12月在苏州市第九人民医院接受腹腔镜手术的118例2型糖尿病患者,随机分为术后进行常规干预的对照组(n=59)和进行抗阻运动训练的训练组(n=59),连续2周。术后1 d、1周、2周时,进行蒙特利尔认知评估量表(MoCA)评估,MoCA评分<26分认为发生认知功能障碍;术后2周时,测定1秒用力呼气容积(FEV1)/用力肺活量(FVC)、每分钟最大通气量(MVV)、左心室射血分数(LVEF),血清白蛋白、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、葡萄糖、肌酐、尿素、尿酸、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、TREM2、NF-κB、STAT3水平。结果术后1 d时,两组间MoCA评分比较的差异无统计学意义(P>0.05);术后1周和2周时,训练组的MoCA评分高于对照组,差异有统计学意义(P<0.05),认知功能障碍发生率低于对照组,差异有统计学意义(P<0.05);术后2周时,两组间血清白蛋白、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、葡萄糖、肌酐、尿素、尿酸比较的差异无统计学意义(P>0.05),训练组的血清IL-1β、IL-6、TNF-α、TREM2、NF-κB、STAT3水平低于对照组,差异有统计学意义(P<0.05)。结论抗阻运动训练改善糖尿病患者腹腔镜手术后认知功能、降低认知功能障碍发生率,抑制TREM2/NF-κB/STAT3通路介导的炎症反应是可能的分子机制。Objective To investigate the effects of resistance exercise training on cognitive function and serum triggering receptor expressed on myeloid cells 2(TREM2),nuclear factorκB(NF⁃κB),signal transducer and activator of transcription 3(STAT3)of diabetic patients after laparoscopic surgery.Methods A total of 118 patients with type 2 diabetes who underwent laparoscopic surgery at Suzhou Ninth People's Hos⁃pital from April 2022 to December 2023 were randomly divided into two groups.The control group(n=59)re⁃ceived routine intervention after surgery,while the training group(n=59)received resistance exercise training for 2 consecutive weeks post⁃surgery.The Montreal Cognitive Assessment(MoCA)was conducted at 1 day,1 week,and 2 weeks after surgery,with a MoCA score of<26 indicating cognitive dysfunction.Additionally,forced expiratory volume at 1 second(FEV1)/forced vital capacity(FVC),minute ventilation volume(MVV)and left ventricular ejection fraction(LVEF),serum albumin,alanine aminotransferase,aspartate aminotransferase,glucose,creatinine,urea,uric acid,interleukin⁃1β(IL⁃1β),interleukin⁃6(IL⁃6),tumor necrosis factor⁃α(TNF⁃α),TREM2,NF⁃κB,STAT3 levels were measured 2 weeks post⁃surgery.Results One day after surgery,there was no significant difference in MoCA scores between the two groups(P>0.05).At one and two weeks after surgery,the MoCA score in the training group was higher than that in the control group,the difference was statistically significant(P<0.05).Additionally,the incidence of cognitive dysfunc⁃tion was lower in the training group compared to the control group,and the difference was statistically sig⁃nificant(P<0.05).At two weeks after surgery,there were no significant differences in serum albumin,ala⁃nine aminotransferase,aspartate aminotransferase,glucose,creatinine,urea and uric acid between the two groups(P>0.05).The levels of serum IL⁃1β,IL⁃6,TNF⁃α,TREM2,NF⁃κB,and STAT3 in the training group were lower than those in the control group,and the difference was s

关 键 词：抗阻训练 2型糖尿病 腹腔镜手术 认知功能障碍 

分 类 号：R587.1[医药卫生—内分泌]