自身免疫性肝病患者血清AGEs、sRAGE表达水平及与肝功能、疾病活动性的关系  

The expression of serum AGEs and sRAGE in patients with autoimmune liver disease and its relationship with liver function and disease activity

作　　者：王菲 王璇[1] 王变 王芳[1] WANG Fei;WANG Xuan;WANG Bian;WANG Fang(Department of Hepatology,Beijing You'an Hospital,Capital Medical University,Beijing,China,100069)

机构地区：[1]首都医科大学附属北京佑安医院肝病科,北京100069

出　　处：《分子诊断与治疗杂志》2024年第12期2394-2397,共4页Journal of Molecular Diagnostics and Therapy

基　　金：北京市优秀人才培养资助项目(202000002146)。

摘　　要：目的探讨自身免疫性肝病(AILD)患者血清晚期糖基化终末产物(AGEs)、可溶性晚期糖基化终产物受体(sRAGE)表达水平及与肝功能、疾病活动性的关系。方法选取2020年3月至2023年10月首都医科大学附属北京佑安医院收治的148例AILD患者作为研究对象(AILD组),根据疾病活动性不同分为活动组(n=102)、缓解组(n=46)。另外选取同时期在本院进行体检的150名健康人作为对照组。采用全自动生化分析仪检测肝功能指标[天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)]水平,采用酶联免疫吸附法检测血清AGEs、sRAGE水平;采用Pearson相关分析探讨AILD患者血清AGEs、sRAGE水平与肝功能指标的相关性;采用受试者工作特性(ROC)曲线评估血清AGEs、sRAGE对AILD患者疾病活动性的预测价值。结果ALDS组血清AGEs水平显著高于对照组,sRAGE水平显著低于对照组,差异有统计学意义(P<0.05)。ALDS组血清AST、ALT、TBIL水平高于对照组,差异有统计学意义(P<0.05)。Pearson相关分析结果显示,AILD患者血清AGEs水平与AST、ALT、TBIL均呈正相关,血清sRAGE水平与AST、ALT、TBIL均呈负相关(P<0.05)。活动组血清AGEs水平明显高于缓解组,sRAGE水平明显低于缓解组,差异有统计学意义(P<0.05)。血清AGEs、sRAGE预测ALDS患者疾病活动性的曲线下面积(AUC)分别为0.852、0.767,低于二者联合预测的0.902。结论血清AGEs、sRAGE水平与AILD患者肝功能、疾病活动性密切相关,两者可作为预测AILD患者疾病活动性的重要指标。Objective To investigate the expression of serum advanced glycation end products(AGEs)and soluble advanced glycation end product receptor(sRAGE)in patients with autoimmune liver disease(AILD)and its relationship with liver function and disease activity.Methods 148 AILD patients admitted to Beijing Youan Hospital affiliated with Capital Medical University from March 2020 to October 2023 were selected as the study subjects(AILD group).They were divided into an active group(n=102)and a re⁃mission group(n=46)based on different disease activity levels.Additionally,150 healthy individuals who un⁃derwent physical examinations at our hospital during the same period were selected as the control group.A fully automated biochemical analyzer to was used to detect liver function indicators such as aspartate amino⁃transferase(AST),alanine aminotransferase(ALT),and total bilirubin(TBIL)levels.Enzyme linked immu⁃nosorbent assay was used to detect serum AGEs and sRAGE levels.Pearson correlation analysis was used to ex⁃plore the correlation between serum AGEs,sRAGE levels,and liver function indicators in AILD patients.The predictive value of serum AGEs and sRAGE for disease activity in AILD patients was evaluated using receiver operating characteristic(ROC)curves.Results The serum AGE levels in the ALDS group were significantly higher than those in the control group,and the sRAGE levels were significantly lower than those in the control group,with statistical significance(P<0.05).The serum levels of AST,ALT,and TBIL in the ALDS group were higher than those in the control group,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that serum AGE levels in patients with AILD was positively correlated with AST,ALT,and TBIL(0.371),while serum sRAGE levels were negatively correlated with AST,ALT,and TBIL(P<0.05).The serum AGE levels in the activity group were significantly higher than those in the remission group,and the sRAGE levels were significantly lower than those in the remission g

关 键 词：自身免疫性肝病 晚期糖基化终末产物 可溶性晚期糖基化终产物受体 肝功能 疾病活动性 

分 类 号：R575[医药卫生—消化系统]