PD-1、PD-L1、MMR蛋白在子宫内膜癌中的表达及与患者临床病理特征的相关性分析  

Expression of PD-1,PD-L1,and Mismatch Repair Proteins in Endometrial Cancer and Their Correlation with Clinical Pathological Features

作　　者：邢雪萍 XING Xueping(Department of Pathology,Third People’s Hospital of Luoyang,Luoyang Henan 471000,China)

机构地区：[1]洛阳市第三人民医院病理科,河南洛阳471000

出　　处：《临床研究》2025年第1期5-8,共4页Clinical Research

摘　　要：目的探究子宫内膜癌(EC)患者的诊断与预后评价,考虑应用程序性死亡受体-1(PD-1)、程序性死亡受体-配体1(PD-L1)、错配修复(MMR)蛋白的价值。方法研究样本共计62例,均选取于洛阳市第三人民医院2019年1月至2024年3月期间收治的EC患者,对其子宫内膜组织开展免疫组化检测,分析PD-1、PD-L1、MMR蛋白水平的表达,同时探讨PD-1、PD-L1、MMR蛋白水平与患者临床病理特征的相关性情况。结果62例EC患者中,PD-1的阳性表达率为62.90%(39/62)、PD-L1的阳性表达率为66.13%(41/62)、MMR蛋白表达缺失率为69.35%(43/62)。表达情况方面,PD-1在国际妇产科联盟分期、细胞分化程度、淋巴结转移以及子宫肌层浸润方面差异有统计学意义(P<0.05);PD-L1在病理学不同类型、国际妇产科联盟分期、细胞分化程度、淋巴结转移以及子宫肌层浸润方面差异有统计学意义(P<0.05);MMR蛋白在细胞分化程度、肿瘤部位、淋巴结转移以及子宫肌层浸润方面差异有统计学意义(P<0.05)。相关性分析结果显示,PD-1在国际妇产科联盟分期、细胞分化程度、淋巴结转移以及子宫肌层浸润方面呈现出正相关;PD-L1在病理学类型、国际妇产科联盟分期、细胞分化程度、淋巴结转移以及子宫肌层浸润方面呈现出正相关;MMR蛋白在细胞分化程度、肿瘤部位、淋巴结转移以及子宫肌层浸润方面呈现出正相关(P<0.05)。结论EC患者的诊断与预后评价方面,考虑应用PD-1、PD-L1、MMR蛋白的价值较为理想,三者在临床病理特征方面具有较为密切的关系,具有临床参考意义。Objective To investigate the diagnostic and prognostic value of programmed cell death protein-1(PD-1),programmed death ligand-1(PD-L1),and mismatch repair(MMR)proteins in patients with endometrial cancer(EC).Methods A total of 62 patients with EC who were treated at the Third People’s Hospital of Luoyang between January 2019 and March 2024 were included.Immunohistochemical staining was performed on their endometrial tissue samples to analyze the expression levels of PD-1,PD-L1,and MMR proteins,and to explore the correlations between these proteins and the clinical pathological features of the patients.Results Among the 62 EC patients,the positive expression rate of PD-1 was 62.90%(39/62),the positive expression rate of PD-L1 was 66.13%(41/62),and the MMR protein expression loss rate was 69.35%(43/62).In terms of expression levels,PD-1 showed statistically significant differences based on the International Federation of Gynecology and Obstetrics(FIGO)staging,degree of cellular differentiation,lymph node metastasis,and myometrial invasion(P<0.05).PD-L1 also demonstrated statistically significant differences in terms of pathological types,FIGO staging,degree of cellular differentiation,lymph node metastasis,and myometrial invasion(P<0.05).MMR proteins showed statistically significant differences based on the degree of cellular differentiation,tumor location,lymph node metastasis,and myometrial invasion(P<0.05).Correlation analyses indicated that PD-1 was positively correlated with FIGO staging,degree of cellular differentiation,lymph node metastasis,and myometrial invasion;PD-L1 was positively correlated with pathological types,FIGO staging,degree of cellular differentiation,lymph node metastasis,and myometrial invasion;and MMR proteins were positively correlated with the degree of cellular differentiation,tumor location,lymph node metastasis,and myometrial invasion(P<0.05).Conclusion The diagnostic and prognostic evaluation of EC patients can consider the values of PD-1,PD-L1,and MMR proteins.The three markers ar

关 键 词：子宫内膜癌 程序性死亡受体-1 程序性死亡受体-配体1 错配修复蛋白 病理特征 

分 类 号：R735[医药卫生—肿瘤]