卡培他滨不同给药方案用于晚期消化道肿瘤中的治疗效果及不良反应分析  

Analysis of the Therapeutic Effects and Adverse Reactions of Different Capecitabine Administration Regimens in Advanced Gastrointestinal Tumors

作　　者：王宁[1] WANG Ning(Department of Gastrointestinal Oncology,Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院消化道肿瘤内科,河南南阳473000

出　　处：《临床研究》2025年第1期51-54,共4页Clinical Research

摘　　要：目的分析晚期消化道肿瘤患者通过不同的卡培他滨给药方案进行治疗的效果。方法选择南阳市中心医院于2022年3月至2023年12月期间收治的60例晚期消化道肿瘤患者,依据随机数字表法将其分为对照组和试验组,各30例。对照组2周为1个疗程,连续治疗3个疗程,每3周后重复1个周期,试验组3周为1个疗程,连续治疗3个疗程,每4周后重复1个周期,对比两组疗效、不良反应发生情况、胃肠道功能、生活质量。结果试验组治疗有效率(86.67%)高于对照组(60.00%),差异具有统计学意义(P<0.05)。试验组不良反应发生率(3.33%)低于对照组(20.00%),差异具有统计学意义(P<0.05)。治疗后试验组血浆胃泌素(GAS)、生长抑素(SS)、胃动素(MTL)水平均高于对照组,血管活性肠肽(VIP)水平低于对照组,差异均有统计学意义(P<0.05)。治疗后试验组免疫球蛋白A(IgA)和CD4^(+)T细胞均高于对照组,差异均有统计学意义(P<0.05)。治疗后试验组的生活质量评分高于对照组,差异具有统计学意义(P<0.05)。结论晚期消化道肿瘤患者通过不同的卡培他滨给药方案进行治疗均可发挥出良好疗效,但相比之下,3周为1个疗程,连续治疗3个疗程这一治疗方案更具效果,优势众多,能够显著降低不良反应发生率,值得应用。Objective To analyze the therapeutic effects of different capecitabine administration regimens in patients with advanced gastrointestinal tumors.Methods A total of 60 patients with advanced gastrointestinal tumors admitted to Nanyang Central Hospital from March 2022 to December 2023 were selected and randomly divided into a control group and an experimental group,with 30 cases in each group.The control group received treatment with a regimen of 2 weeks per cycle,for 3 consecutive cycles,followed by one cycle every 3 weeks.The experimental group was treated with a regimen of 3 weeks per cycle,for 3 consecutive cycles,followed by one cycle every 4 weeks.The therapeutic efficacy,incidence of adverse reactions,gastrointestinal function,and quality of life were compared between the two groups.Results The effective treatment rate in the experimental group(86.67%)was higher than that in the control group(60.00%),with a statistically significant difference(P<0.05).The incidence of adverse reactions in the experimental group(3.33%)was lower than that in the control group(20.00%),with a statistically significant difference(P<0.05).After treatment,the levels of plasma gastrin(GAS),somatostatin(SS),and motilin(MTL)in the experimental group were higher than those in the control group,while the level of vasoactive intestinal peptide(VIP)was lower in the experimental group,with significant differences(P<0.05).After treatment,the levels of immunoglobulin A(IgA)and CD4^(+)T cells in the experimental group were also higher than those in the control group,with significant differences(P<0.05).The quality of life scores in the experimental group were higher than those in the control group,with a statistically significant difference(P<0.05).Conclusion Both capecitabine administration regimens demonstrated good therapeutic effects in patients with advanced gastrointestinal tumors.However,the regimen of 3 weeks per cycle for 3 consecutive cycles proved to be more effective,with numerous advantages,significantly reducing the incidence of

关 键 词：消化道肿瘤 卡培他滨 药物治疗 不良反应 

分 类 号：R735[医药卫生—肿瘤]